Chemistry of Natural Products
Part of this Programme
Level of Qualification|Semesters|ECTS
Bachelor | Semestral | 5
Year | Type of course unit | Language
2 |Mandatory |Português
Total of Working Hours | Duration of Contact (hours)
125 | 60
Recommended complementary curricular units
Prerequisites and co-requisites
Introduction: natural products, definitions, history of natural products in various areas such as medicine and food. Procedures in obtaining the raw material. Biotechnical production of drugs (antibiotics, production of metabolites in microorganisms and cell culture, formation of biologically active pharmacological compounds from plants, Classification of natural products, carbohydrates: monosaccharides, disaccharides, natural products and carbohydrates. natural derivatives of xymeric acid Natural products derived from acetate Natural products derived from amino acids Alkaloids Characterization of natural compounds: mass spectrometry, IV and NMR Laboratory Practices Extraction of natural compounds Purification of natural products Application of fractionation and purification techniques Assessment of biological potential (antioxidant activity) of extracts.
Acquire a global perspective of the study of applied chemistry of plants and their interaction with other sciences. Acquire the basic knowledge of the chemistry of natural products and scientific methods to apply in the laboratory or industry in specific areas such as Pharmaceutical, Environment, Food and Health. Develop observation, reasoning and logic in problem solving and drawing conclusions . Prepare the student in the knowledge and handling of extraction material in the laboratory following risk and safety rules.
Knowledge, abilities and skills to be acquired
Allow students to distinguish natural molecules extracted from plants, microorganisms and synthetic molecules and relate their structures to their reactivity and biological potential. Know how to extract and synthesize in the laboratory, purify and identify using traditional and modern techniques.
Teaching methodologies and assessment
The UC will be taught in the form of theoretical lectures delivered with power-point support and on the board. The versions (in pdf) are available through "Moodle", as a support for students. Exercises will be made available, as well as their resolutions. Parallel to the theoretical classes students will attend laboratory classes, aiming at several aspects referred to in theory. In the final classification of the subject it is considered 50% for the theoretical evaluation and 50% for the laboratory evaluation. Theoretical evaluation: Continuous evaluation with two frequencies (the theoretical grade will be the weighted average of the two frequencies). If you fail in the continuous evaluation, students will go to 1st or 2nd period exams. The practical evaluation corresponds to the weighted average of reports and oral presentation of a topic. The student is proficient in the CU if he / she obtains a grade of 10 or higher (for a maximum of 20 values) corresponding to the average of the theoretical grade 50% + practical grade 50%.
Organic Chemistry, T. W . Graham Solomons, Craig B. Fryhle, Scott A. Snyder, Wiley, 2013
Organic Chemistry-, K. P. Volhardt, N.E. Schore, W.E. Freeman and Company, 6Ed, 2010.
Química Orgânica-, R. Morrison, R. Boyd, Fundação Calouste Gulbenkian, 11 edição, 2011.
Organic chemistry-, J. Chayden, N. Greeves, S. Warren and O. Wothers, Oxford University, Press 2001.
P.M. Dewick, Medicinal Natural Products, Wiley 2002.
A.M. Lourenço, Problems em Biossintese de produto s Naturais, EDINOVA, 1998.
K.B.G. Torsseli, Natural Product Chemistry, A mechanistic and ecological approa ch, APOTEKARSOCIETETEN, 1997.
Chemistry of Natural Products- S. V. Bhat; B.A. Nagasampagi; M. Sivakumar, Springer (New York) / Narosa (New Delh i), 2005.
P. M. Dewick "Medicinal Natural Products" A Biosynthetic Approach¿, Wiley, Chichester, 2009.