Toxicology and Pharmacotoxicology
Part of this Programme
Level of Qualification|Semesters|ECTS
Bachelor; Master Degree | Trimestral | 7
Year | Type of course unit | Language
5 |Mandatory |Português
Total of Working Hours | Duration of Contact (hours)
175 | 90
Recommended complementary curricular units
Prerequisites and co-requisites
Principles of Toxicology
Carcinogenicity of drugs
Adverse Drug Effects
Identification, classification and mechanisms
Pharmacogenetics and adverse drug reactions
Safety assessment of pharmaceuticals
Toxicity on Organs and Systems
Structures and function
Conditions that determine toxicity
Toxicant-induced responses of organs and systems
Drug-induced toxic effects
Definition and general aspects
Management of drug overdose
Toxicity testes de in vitro
Determination of xenobiotics in environmental and or biologic samples
Critical evaluation of scientific information
Assessment of toxicological parameters
Critical analysis of toxicological information for the society
- Identify and evaluate the risk associated to the actions of the development of new drugs.
- Establish security criteria for the use of drugs.
- To design toxicological studies applied to xenobiotics in general and particularly to candidate molecules to be used as drugs.
- Know the adverse effects of drugs, expressed on the different organs and systems, as well the actions to take when they occur.
Knowledge, abilities and skills to be acquired
- Transmit the information concerning toxicology in general as well the one the drugs to the healthcare professionals, patients and society in general, in order to promote the correct utilization of drugs or in intoxication cases.
- To carry out qualitative and quantitative studies of xenobiotics by autoradiography.
- To perform studies on chemical toxicity in vitro.
- Prepare, discuss and execute protocols to quantify xenobiotics in organic fluids by HPLC techniques.
- Evaluate and discuss clinical cases resulting from intoxications with drigs and other xenobiotics.
Teaching methodologies and assessment
Teaching by theoretical and laboratory classes aiming a deepening of the knowledge. Theoretical-practical sessions and seminars are made to improve the capacities to search, compile, analyse and evaluate reports in scientific literature and databases. The evaluation may be by continuous assessment or by a final examination. Continuous assessment comprises: attendance and performance 10% (A); two written tests 65% (B); a laboratory mini-project 5% (C); the presentation and discussion of laboratory work, 10% (D); the presentation and discussion of scientific papers, 10% (E). Final classification = A (10%) + B (65%) + C (5%) + D (10%) + E (10%).
Oral evaluations as complement of written evaluations.
The worker-student who opts for continuous evaluation must comply with the requirements set out above.
Evaluation by final exam applies to students who opt for it, covering the whole of the syllabus. The grade improvement is attained by written evaluation, comprising the entire syllabus.
Samuelsson, G., & Bohlin, L. (2009). Drugs of natural origin: A treatise of pharmacognosy (6th rev. ed.). Stockholm, Sweden: Apotekarsocieteten.
Bruneton, J. (1999). Pharmacognosy, phytochemistry, medicinal plants (2nd ed.). Paris: Editions TEC & DOC
Evans, W., & Evans, D. (2009). Trease and Evans' pharmacognosy (16th ed.). Edinburgh: WB Saunders.
Farmacopeia portuguesa IX (Ed. oficial ed.). (2009). Lisboa: Imprensa Nacional, Casa da Moeda.