filmeu

Docente
Maria Catarina Figueiral Da Silva Pereira Leite

Maria Catarina Figueiral Da Silva Pereira Leite
cat***@ulusofona.pt
1217-F792-8183
0000-0001-5407-3983

Resume

Catarina Pereira-Leite (CPL) is currently an Assistant Professor at School of Health Sciences and Technologies of Lusófona University and she is an integrated member of CBIOS - Research Center for Biosciences & Health Technologies and a collaborator of LAQV, REQUIMTE. CPL received her PhD Degree in Pharmaceutical Sciences / Biological Sciences (Biochemistry) from Faculty of Pharmacy, University of Porto (FFUP) and Chemistry Institute, University of São Paulo (IQ-USP), under a cotutelle agreement, in December 2017. CPL graduated in Pharmaceutical Sciences (Integrated Master's) from FFUP in 2012. Understanding biological barriers and finding nanoways of overcoming them are the main research interests of CPL. Initially, her research was focused on understanding biological membranes for the development of more effective and safer anti-inflammatory drugs. More recently, her research line has also evolved towards the design of bioinspired nanosolutions for pharmaceutical and cosmetic applications. In 2021, the exploratory project "Bioinspired materials in nanosolutions to tackle atopic dermatitis" submitted by CPL as principal investigator was recommended for funding by FCT, boosting her career development. CPL published more than 20 full articles in peer-reviewed international journals, as well as participated in various (inter)national conferences with oral and poster communications. She has been involved in the supervision of PhD, MSc, and BSc students and in teaching activities for graduation programs and advanced training. She has also been involved in the coordination and participation of various scientific outreach activities for general society and high school students.

Graus

  • Mestrado
    Integrated Master's in Pharmaceutical Sciences
  • Licenciatura
    Bachelor's Degree in Basic Studies in Pharmaceutical Sciences
  • Doutoramento
    PhD in Pharmaceutical Sciences / Biological Sciences (Biochemistry)

Publicações

Journal issue

  • Delivery Systems Based on Innovative Nanomaterials, 12
  • Abstract Book - InnovDelivery '22 - I Lusophone Meeting on Innovative Delivery Systems

Journal article

  • 2023-03, Rational design of magnetoliposomes for enhanced interaction with bacterial membrane models, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • 2023-02-08, Revealing the Protective Effect of Topically Applied Cymbopogon citratus Essential Oil in Human Skin through A Contact Model, Cosmetics
  • 2022-07, Cymbopogon citratus (DC.) Stapf essential oil: Unraveling potential benefits on human skin, Journal Biomedical and Biopharmaceutical Research
  • 2022-04-11, Delivery Systems Based on Innovative Nanomaterials, Nanomaterials
  • 2022-01-15, Nanodelivery Strategies for Skin Diseases with Barrier Impairment: Focusing on Ceramides and Glucocorticoids, Nanomaterials
  • 2021-12-31, Single versus mixed edge activators in caffeine-loaded transfersomes: physicochemical and cytotoxicity assessment, Journal Biomedical and Biopharmaceutical Research
  • 2021-12-21, TransfersomILs: From Ionic Liquids to a New Class of Nanovesicular Systems, Nanomaterials
  • 2021-05-11, Characterization of Kefir Produced in Household Conditions: Physicochemical and Nutritional Profile, and Storage Stability, Foods
  • 2021-04-13, Interface-Mediated Mechanism of Action—The Root of the Cytoprotective Effect of Immediate-Release Omeprazole, Journal of Medicinal Chemistry
  • 2021-04-13, Interface-Mediated Mechanism of Action—The Root of the Cytoprotective Effect of Immediate-Release Omeprazole, Journal of Medicinal Chemistry
  • 2021-03, Passive diffusion of ciprofloxacin and its metalloantibiotic: a computational and experimental study, Journal of Molecular Biology
  • 2020-12-29, Unraveling the Role of Drug-Lipid Interactions in NSAIDs-Induced Cardiotoxicity, Membranes
  • 2020-11, Optimization of gallic acid-loaded transfersomes using a Box-Behnken factorial design, Biomedical and Biopharmaceutical Research Journal
  • 2020-04-26, Neutral Diclofenac Causes Remarkable Changes in Phosphatidylcholine Bilayers: Relevance for Gastric Toxicity Mechanisms, Molecular Pharmacology
  • 2019-11-26, Phosphatidylcholine bilayers trigger the degradation of licofelone, Journal Biomedical and Biopharmaceutical Research
  • 2019-01, Licofelone-DPPC Interactions: Putting Membrane Lipids on the Radar of Drug Development, Molecules
  • 2018-09, Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers?, Colloids and Surfaces B: Biointerfaces
  • 2018-05, Acemetacin–phosphatidylcholine interactions are determined by the drug ionization state, Physical Chemistry Chemical Physics
  • 2018, Acemetacin-phosphatidylcholine interactions are determined by the drug ionization state, Physical Chemistry Chemical Physics
  • 2017, Nonsteroidal Anti-Inflammatory Therapy: A Journey Toward Safety, Medicinal Research Reviews
  • 2014, Bioquim4x: um jogo didático para rever conceitos de bioquímica., Revista de Ensino de Bioquímica
  • 2013, Interaction of nonsteroidal anti-inflammatory drugs with membranes: In vitro assessment and relevance for their biological actions, Progress in Lipid Research
  • 2013, In vitro assessment of NSAIDs-membrane interactions: Significance for pharmacological actions, Pharmaceutical Research
  • 2013, Evaluation of the structure-activity relationship of rifabutin and analogs: A drug-membrane study, ChemPhysChem
  • 2013, Biophysical characterization of the drug-membrane interactions: The case of propranolol and acebutolol, European Journal of Pharmaceutics and Biopharmaceutics
  • 2012, Interaction of celecoxib with membranes: The role of membrane biophysics on its therapeutic and toxic effects, Journal of Physical Chemistry B
  • 2011, NSAIDs interactions with membranes: A biophysical approach, Langmuir

Thesis / Dissertation

  • 2017-12-07, PhD, NSAIDs developed with recent strategies: a biophysical approach to evaluate their therapeutic and toxic effects

Book chapter

  • 2018, Nanodelivery systems for NSAIDs: Challenges and Breakthroughs, Nanoparticles in Life Sciences and Biomedicine, Pan Stanford Publishing

Conference poster

  • 2023-02-06, Optimization of rutin-loaded cerosomes: a step forward for the management of dermatological conditions, 4th SPLC-CRS Young Scientists Meeting
  • 2023-02-06, Exploring the innovative TransfersomILs for the cutaneous delivery of hydroxycinnamic acids, 4th SPLC-CRS Young Scientists Meeting
  • 2022-11-11, The Portuguese Physiology Roadmap – From molecules to the individual – perspectives from CBIOS
  • 2022-11-11, Probing the impact of TransferomILs containing rutin in skin physiology — cytotoxicity studies, 2nd International Meeting of the Portuguese Society of Physiology
  • 2022-11-11, New perspectives in the approach to skin barrier dysfunction - using lipid nanoparticles based on insect biomass to improve dexamethasone delivery, 2nd International Meeting of the Portuguese Society of Physiology
  • 2022-10-21, Improving the performance of SLNs - combining lipids extracted from larvae biomass and choline-based ILs, 5º Encontro de Biotecnologia Medicinal/2nd Iberian Congress on Medicinal Biotechnology
  • 2022-03, Stratum corneum lipids as the basis of nanoparticles for epidermal regeneration. , COSMETINNOV
  • 2022-03, Effects of a formulation containing Cymbopogon citratus essential oil on human skin. , COSMETINNOV
  • 2022-03, Development of lipid nanoparticles based on insect larvae biomass for skin delivery., COSMETINNOV
  • 2021-11-18, Innovative formulations loading phytochemicals to tackle skin ageing: preliminary studies, II Bio.Natural – Bioactive Natural Products Research Meeting
  • 2021-11-03, Innovative transfersomes for the transdermal nanodelivery of ibuprofen., CIFARP 2021 - 13th International Congress of Pharmaceutical Sciences
  • 2021-11, Using lipids extracted from black soldier fly larvae for nanoparticles development - Preliminary studies., II Bio.Natural – Bioactive Natural Products Research Meeting.
  • 2021-08-18, Desenvolvimento de nanopartículas lipídicas baseadas na composição do estrato córneo para regeneração epidérmica. , 33º Congresso Brasileiro de Cosmetologia
  • 2021-05, Optimization of Ibuprofen-loaded Transfersomes for Transdermal Delivery., EuroNanoForum 2021 International Online Conference
  • 2020-11-23, Preliminary studies to design ibuprofen-loaded transfersomes for cutaneous applications. , IV CBIOS Seminar
  • 2020-11-03, Development of rutin delivery systems assisted by a choline-amino acid ionic liquid, Encontro Ciência 2020
  • 2020-06, Optimization of a vesicular system for the transdermal delivery of acidic compounds, Controlled Release Society Virtual Annual Meeting: 2020 Vision for Global Impact
  • 2019-07, Quality by design development of fusogenic magnetoliposomes, XXVI Encontro Nacional da Sociedade Portuguesa de Química
  • 2019-07, New anti-inflammatory drugs: less, equal or more topical actions on membrane lipids?, XXVI Encontro Nacional da Sociedade Portuguesa de Química
  • 2019-07, Membrane-permeabilizing activity of NSAIDs: a role in cardiotoxicity?, Joint 12th EBSA-10th ICBP-IUPAP Biophysics Congress
  • 2019-06, Lipid interfaces in drug development: focusing on nonsteroidal anti-inflammatory drugs, 2019 FEBS Advanced Lecture Course - Biological Surfaces and Interfaces: The Mechanistic View
  • 2019-02, New anti-inflammatory drugs: novel or old effects on membrane lipids?, 12th Meeting of young researchers of University of Porto (IJUP’19)
  • 2019-02, Is there a role for membrane lipids on drug-induced cardiovascular toxicity?, 12th Meeting of young researchers of University of Porto (IJUP’19)
  • 2018-06, Biophysical interactions between omeprazole and lipid membrane models: unveiling an additional mechanism of action, 6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics
  • 2018-02, Drug-membrane interaction studies on revealing NSAIDs-induced cardiovascular toxicity, 11th Meeting of young researchers of University of Porto (IJUP’18)
  • 2017-02, NSAIDs cardiovascular risk: a role for drug effects on membranes?, 10th Meeting of young researchers of University of Porto (IJUP’17)
  • 2016-06, Unraveling the acemetacin effects on phosphatidylcholine bilayers, 5th International Iberian Biophysics Congress
  • 2015-09, Avaliação in vitro da interação da acemetacina com lipídios de membrana, 23º Simpósio Internacional de Iniciação Científica da Universidade de São Paulo (SIICUSP)
  • 2015-07, In vitro study of NSAIDs-membrane interactions: the case of indomethacin and derivative, 10th European Biophysics Congress
  • 2014-11, Membrane lipids biophyics and structure in disease: relevance for drug delivery therapies, XX Encontro Luso-Galego de Química
  • 2014-11, In vitro assessment of NSAIDs-membrane interactions: the case of diclofenac and novel derivative, XX Encontro Luso-Galego de Química
  • 2014-06, The role of the membrane fluidity increase by indomethacin and derivatives in their gastrointestinal toxic effects, 20th International Symposium on Surfactants in Solution
  • 2014-05, The effect of indomethacin and derivatives on the phase transition parameters of DMPC, XLIII Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular
  • 2013-10, NSAIDs interactions with supported lipid bilayers: An atomic force microscopy study, Bioimaging 2013 - International Symposium in applied Bioimaging from molecule to man
  • 2013-10, NSAIDs interactions with membranes: the role of membrane biophysics on its therapeutic and toxic effects, Biophysics in drug discovery, NovAliX conference
  • 2013-10, A biophysical approach to diet compounds-membrane interactions, Biophysics in drug discovery, NovAliX conference
  • 2013-05, Interação da indometacina e do nimesulide com modelos membranares, 36ª Reunião Anual da Sociedade Brasileira de Química
  • 2013-02, Production of innovative trojan horses for the treatment of inflammatory chronic conditions, 6th Meeting of young researchers of University of Porto (IJUP’13)
  • 2013-02, Evaluation of the structure-activity relationship of rifabutin and analogues: a drug-membrane study, 6th Meeting of young researchers of University of Porto (IJUP’13)
  • 2012-07, Electrophoretic Mobility, Zeta Potential and Dissociation Degree of Vesicles prepared with Mixtures of Charged and Zwitterionic Lipids suggest that ion condensation determines surface potential above ten percent charged lipid in the mixture, Colloids and Nanomedicine
  • 2012-05, Effect of mixtures of charged and zwitterionic lipids on vesicles properties: size, electrophoretic mobility, zeta potential and dissociation degree, XLI Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular
  • 2011-10, Biomimetic membranes applied to the study of drug-membrane interactions: the case of celecoxib, 8th Lipidomics Meeting – Membranes and bioactive lipids
  • 2011-07, NSAIDs interactions with membranes: a biophysical approach, 4th Iberian Meeting on Colloids and Interfaces (RICI4)
  • 2011-07, Lipid-drug interaction: biophysical and structural effects of Celecoxib on membrane mimetic systems, 4th Iberian Meeting on Colloids and Interfaces (RICI4)
  • 2011-07, Lipid monolayers as resourceful tools to study the activity of enzymes and drugs at the interface, 4th Iberian Meeting on Colloids and Interfaces (RICI4)
  • 2010-11, The interaction of Celecoxib with membranes: a biophysical study, XVI Encontro Luso-Galego de Química
  • 2010-02, In vitro assessment of meloxicam effects on biomembranes, 2nd Meeting of young researchers of University of Porto (IJUP’09)
  • 2009-04, Studies for improving therapeutic effects of drugs: the role of membrane biophysics and drug-membrane interactions, Meeting on Nanotechnology, Liposome and Health

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