Class Genetics

Genetics studies genes and how characteristics are transmitted from generation to generation. Biochemestry studies cellular chemical reactions. Hence, this Curricular Unit is fundamental for this study cycle, giving the basis for a better understanding of cellular chemical processes.

In the theorical component students will be introduced to basic concepts of gene expression, which will be able to apply in the lab (pratical component) using several methodoligies of DNA analysis.

I Genetic material struture and organization:

1. DNA and cromatine
2. Information transmission: DNA replcation and chromosome structure as a phsysical vehicle of genetic information, structure and funtion of replication origins, centromeres and telomeres

II Genetic expression processes transcription and translation:

1. Transcription regulation via regulatory proteins and conformation

III Eukariotes genome constitution

IV Genetic information innovation processes:

1. Mutation and DNA repair mechanisms
2. meiotic recombination and transposable elements

V Classical genetic analysis and interconnection with meiotic division:

1. Independent gene segregation (multiple alleles, lethal alleles, sex-linked genes interaction) and genetic connection

VI Basic molecular genetic techniques - experimental classes:

1. DNA extration from eukariotic cells and plasmids
2. Nucleic acid analysis with spectrophtometry and electrophoresis

Students will prepare their seminars based on innovative methodologies in the context of applications of current use: diagnosis and prognosis of pathologies, and mechanisms of genetic regulation, among others.

• Griffiths, Anthony J.F.; Wessler, Susan R.; Carroll, Sean B.; Doebley, John. Introduction to Genetic Analysis 11 ed. W.H. Freeman. 2015 ISBN-13: 978-1464109485