Food metabolites and the impact of microbiota

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The impact of food and its components on the organism is of prime importance, a particular focus will also reside on effects on the structure (composition) and function (physiology) of the organism’s microbiota. Nutrition and the microbiota have a strong interconnection, i.e. the diet can change the microbiota, which in turn metabolizes the individual components of the diet. This interplay impacts significantly on the health of the host. This module will focus in training the students to identify the metabolites derived from the metabolic action of the microbiota. Moreover, the impact of a nutritional intervention in microbiota composition will be evaluated by analyzing 16S data.

Program

Lectures

• Interactions of the gut microbiota with dietary compounds
  • David Berry, Centre for Microbiology and Environmental Systems Science, University of Vienna
• Polyphenols bioactivity: the role of microbiota
  • Ana Faria, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa
• In vitro gut microbiome biotransformation models.
  • Olivier Mortelé, University of Antwerp, Belgium
• High resolution LC-MS analysis using suspect and non-targeted screening workflows to identify colonic metabolites.
  • Philippe Vervliet, University of Antwerp, Belgium

Practical Classes (hands-on)

• Colonic metabolite identification by non-targeted screening 
• 16S rRNA gene sequencing data analysis