Docente
Liane Isabel Ferreira Moura

Graus

• Licenciatura
  Bioquímica
• Doutoramento
  Engenharia Química - Biotecnologia
• Pós-Graduação
  Pedagogy for the Higher Education

Publicações

Journal article

• 2024-04, Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy, Advanced Functional Materials
• 2023, Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors, Advanced Science
• 2022, Multifunctional nanovaccine synergizes with OX40 agonist in triple-negative breast cancer, FEBS Open Bio
• 2021-10, Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin, Experimental Gerontology
• 2021-05, Preclinical models and technologies to advance nanovaccine development, Advanced Drug Delivery Reviews
• 2020-08, Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes, Brain Research Bulletin
• 2019-08-05, Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators, Nature Nanotechnology
• 2019-08, Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer, Journal of Controlled Release
• 2019-04, Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain, Brain Research Bulletin
• 2019, Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders, Materials Horizons
• 2018, a-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma, Acta Biomaterialia
• 2017-12, Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation, Seminars in Immunology
• 2017-08-10, Poly-glutamic dendrimer-based conjugates for cancer vaccination – a computational design for targeted delivery of antigens, Journal of Drug Targeting
• 2017, Multifunctional poly (glutamic acid) dendrimer as delivery system of tumor associated antigens for cancer immunotherapy - a computational design approach, The FEBS Journal
• 2017, Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression, Diabetologia
• 2015-12, Regulatory aspects on nanomedicines, Biochemical and Biophysical Research Communications
• 2014, The effect of neurotensin in human keratinocytes - implication on impaired wound healing in diabetes, Experimental Biology and Medicine
• 2014, Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice, Biochimica et Biophysica Acta - Molecular Basis of Disease
• 2014, Neurotensin Decreases the Proinflammatory Status of Human Skin Fibroblasts and Increases Epidermal Growth Factor Expression, International Journal of Inflammation
• 2014, Chitosan-based dressings loaded with neurotensin - An efficient strategy to improve early diabetic wound healing, Acta Biomaterialia
• 2013, Recent advances on the development of wound dressings for diabetic foot ulcer treatment--a review, Acta Biomaterialia
• 2013, Neurotensin Modulates the Migratory and Inflammatory Response of Macrophages under Hyperglycemic Conditions, BioMed Research International
• 2013, Collagen-based dressings loaded with neurotensin repair ulcers in diabetic mice, Virchows Archiv
• 2012, Neurotensin and collagen dressings improve diabetic wound healing, Diabetologia
• 2012, Neurotensin and Chitosan-based dressings repair ulcers of diabetic mice, Virchows Archiv
• 2011, Neurotensin downregulates the pro-inflammatory properties of skin-dendritic cells and increases epidermal growth factor expression, Diabetologia
• 2011, Neurotensin and chitosan-based dressings: a new approach for diabetic wound healing treatment, Diabetologia
• 2011, Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells, PLoS ONE
• 2010, The Role of Neurotensin in Wound Healing in Diabetic and iNOS Knockout Mice, Diabetes
• 2010, Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells, Journal of Cellular Biochemistry
• 2009, Modulation effect of catechin in angiogenesis and inflammation, The FASEB Journal
• 2009, Establishing the molecular modulation of the inflammation by xanthohumol and its metabolites in endothelial and smooth muscle cells, The FASEB Journal

Thesis / Dissertation

• 2013, PhD, Development of novel therapeutic approaches for wound healing in diabetes

Book chapter

• 2018, Functional moieties for intracellular traffic of nanomaterials., Biomedical Applications of Functionalized Nanomaterials, Elsevier

Conference paper

• Translational nanotechnology-based cancer vaccine to re-educate host immune response against metastatic cancers, Proceedings of the American Association for Cancer Research Annual Meeting 2023
• The role of neurotensin in wound healing in diabetic and iNOS knockout mice, 70th Scientific Sessions of the American Diabetes Association
• Streptozotocin-induced type-1 diabetes triggers deregulation of cerebral glucose metabolism identical to genetic deletion of the CB1 cannabinoid receptor, 8th FENS Forum of Neuroscience 2012
• PO-416 A novel multifunctional polypeptide-based platform as an immunotherapeutic approach for melanoma
• Neurotensin and collagen dressings improve diabetic wound healing, Annual Meeting of Portuguese Society of Diabetology, 2013
• Neurotensin and chitosan-based dressings: a new approach for diabetic wound healing treatment, 47th EASD Annual Meeting, 2011
• Neurotensin and chitosan-based dressings: a new approach for diabetic wound healing treatment, 10º Congresso Português de Diabetes, 2012
• Neurotensin and Chitosan-based dressings repair ulcers of diabetic mice, European Conference of Pathology
• Multifunctional nanovaccine synergizes with OX40 agonist in triple-negative breast cancer, 46th FEBS Congress
• Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression, 53rd EASD Annual Meeting
• Collagen-based dressings loaded with neurotensin repair ulcers in diabetic mice, 24th European Congress of Pathology
• CB1 cannabinoid receptor can contribute to early skin aging in diabetes, Anual Meeting of Portuguese Society of Diabetology, 2013
• 2018, A novel multifunctional polypeptide-based platform as an immunotherapeutic approach for melanoma, 25th Biennial Congress of the European Association for Cancer Research
• 2017-09-01, Multifunctional poly (glutamic acid) dendrimer as delivery system of tumor associated antigens for cancer immunotherapy-a computational design approach, 42nd FEBS Congress, 2017
• 2017, Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression
• 2016, Computational design of a novel poly-glutamic dendrimer-based platform as an anticancer therapeutic approach, 41st FEBS Congress
• 2015, Diabetes Decreases CB1 Cannabinoid Receptor Expression Promoting Early Skin Aging, 75th Scientific Sessions of the American Diabetes Association
• 2012, Neurotensin and collagen dressings improve diabetic wound healing, 48th EASD Annual Meeting
• 2011, Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells in a fibrin gel

Conference abstract

• 2024-03-15, Unlocking solid tumors to nano-immunotherapy, Proceedings of the American Association for Cancer Research Annual Meeting 2024
• 2023, Abstract 835: Translational nanotechnology-based cancer vaccine to re-educate host immune response against metastatic cancers, AACR Annual Meeting 2023

Conference poster

• 2024-02-14, Polyoxazoline Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and PD-1 blockade against Solid Tumors, XV Spanish-Portuguese Conference on Controlled Drug Delivery
• 2024-02-14, From cold to hot: Nanotechnology-based immunotherapy driving effective PDAC anti-tumor response, XV Spanish-Portuguese Conference on Controlled Drug Delivery
• 2024-02-14, Combined nano-immunotherapy to regulate immune profiling and tumor-associated stroma in breast cancer, XV Spanish-Portuguese Conference on Controlled Drug Delivery
• 2023-10-26, Nano-immunotherapy for melanoma – a window of translation oncology, III ASPIC-ASEICA International Meeting
• 2023-10-21, Nano-immunotherapy to modulate immune cells in pancreatic cancer, "O Futuro Hoje: Novas Terapêuticas Moleculares e Biológicas¿
• 2023, Translational nanotechnology-based cancer nanovaccine to re-educate host immune response against melanoma brain metastases, Gordon Research Conference on Cancer Nanotechnology and Gordon Research Seminar on Cancer Nanotechnology
• 2022-10-19, Precision Nanomedicine-based Immunotherapy to Overcome Immunosuppression Against Metastatic Melanoma. , Champalimaud Research Symposium: Tumor Microenvironment (from cancer initiation to metastasis)
• 2022-07-04, Multifunctional Nano-therapy to Overcome Pancreatic Cancer Immune Evasion, 13th iMed.ULisboa – Postgraduate Students Meeting
• 2022-06-20, Targeted nanovaccine as a powerfull platform to improve immune modulation and checkpoint therapies in colorectal cancer, 28th Congress of the European Association for Cancer Research
• 2022-06-20, Multifunctional nanovaccine synergizes with OX40 agonist in triple-negative breast cancer, 28th Congress of the European Association for Cancer Research
• 2022-06, Targeted nanovaccine as a powerful platform to improve immune modulation and checkpoint therapies in colorectal cancer, EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine
• 2022-05-23, Multivalent branched poly-l-glutamic acid-based nanovaccine sensitizes melanoma to anti-PD1 therapy, 13th International Symposium on Polymer Therapeutics: from Laboratory to Clinical Practice
• 2022-05-23, Multifunctional Polymeric Nanoplatform to Overcome Pancreatic Cancer Immune Evasion, 13th International Symposium on Polymer Therapeutics: from Laboratory to Clinical Practice
• 2022-05-04, Student centered teaching towards critical thinking in pharmaceutical technology, Jornadas Pedagógicas da Universidade de Lisboa - Ensino 4.0: Transição Digital
• 2021-10-15, Multivalent branched polypeptide-based nanovaccine as a novel immunotherapeutic approach for melanoma, LPCC_Cutaneous Melanoma: From Where to Where?
• 2021-06-30, Precision Nanomedicine-based therapeutics to regulate immunosuppression against metastatic melanoma, Virtual iMed.ULisboa Meeting 2021
• 2021-06, Multifunctional nanovaccine synergizes with OX-40 agonist in triple-negative breast cancer, EACR2021
• 2021, Precision Multifunctional Nanomedicines to Regulate Immunosuppression Against Melanoma Brain Metastasis, Cutaneous Melanoma: From Where to Where?,
• 2020-03-02, Targeted nanovaccine as a powerful platform to improve immune modulation therapy in colorectal cancer, EACR-AACR-ASPIC Conference: Tumor Microenvironment
• 2020-03, Targeted nanovaccine as a powerfull platform to improve immune modulation therapy in colorectal cancer, EACR-AACR Basic and Translational Research Conference in partnership with ASPIC Tumor Microenvironment
• 2020-03, Multifunctional nanovaccine synergizes with immune checkpoint therapy against triple-negative breast cancer, EACR-AACR Basic and Translational Research Conference in partnership with ASPIC Tumor Microenvironment
• 2020-03, Functionalized nanobiomaterials as novel combination immunotherapies in cancer., EACR-AACR-ASPIC Conference: Tumor Microenvironment
• 2019-05-23, Multivalent polypeptide-based nanovaccine as anti-cancer immunotherapeutic strategy for melanoma, 17th Annual Meeting of the Association for Cancer Immunotherapy - CIMT
• 2019-01-24, Nanotechnology in medicine and challenges for the manufacturing of nanomedicines., 14th Meeting of the Spanish Society of Pharmaceutics and Pharmaceutical Technology
• 2019, Targeted nanovaccine as a powerfull platform to treat colorectal cancer., EACR-AACR-ASPIC Conference: Nanotechnology in Cancer: Engineering for Oncology,
• 2018-07-30, PO-416 A novel multifunctional polypeptide-based platform as an immunotherapeutic approach for melanoma, 25th Biennial Congress of the European Association for Cancer Research.
• 2018-07-24, Nanoparticle-based vaccine improved the anti-tumor efficacy of the immune checkpoint co-stimulator OX40 in breast carcinoma, 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting
• 2018-07-24, Nanoparticle- based vaccine improved OX40 anti-tumor efficacy in breast cancer, 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting
• 2018-07-22, Polymeric nano-vaccines improved OX40 anti-tumor efficacy against breast cancer, Controlled Release Society Annual Meeting and Exposition.
• 2018-07-09, A novel multifunctional polypeptide-based platform as an immunotherapeutic approach for melanoma, Frontiers in Immunomodulation and Cancer Therapy
• 2018-07-02, PO-415 Multivalent polymeric nanoparticles as an innovative cancer immunotherapy for colorectal cancer, 25th Biennial Congress of the European Association for Cancer Research
• 2018-06-30, Multivalent polymeric nanoparticles as an innovative cancer immunotherapy for colorectal cancer, EACR25: From Fundamental Insight to Rational Cancer Treatment
• 2018-05-28, A novel multifunctional polypeptide-based nanosystem as an anti-cancer immunotherapeutic approach for melanoma. , 12th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice
• 2018-05-16, Multivalent polymeric nanoparticles for combinatorial innovative colorectal cancer immunotherapy and immunomodulation., 16th CIMT Annual Meeting – Pushing Frontiers in Cancer Immunotherapy
• 2018-05-10, PLGA-based nanoparticles for combinatorial innovative colorectal cancer immunotherapy and immunomodulation., 3rd ASPIC International Congress
• 2018-05-10, Multivalent PLGA-based nanoparticles for combinatorial innovative colorectal cancer immunotherapy and immunomodulation, 3rd ASPIC International Congress
• 2018-01-17, Multifunctional polypeptide-based platform as an anti-cancer immunotherapeutic approach for melanoma., XII Spanish-Portuguese Conference on Controlled Drug Delivery
• 2018, A novel multifunctional polypeptide-based nanosystem as an anti-cancer immunotherapeutic approach for melanoma, Frontiers in Immunomodulation and Cancer Therapy
• 2017-09-14, Multifunctional poly (glutamic acid) dendrimer as delivery system of tumor associated antigens for cancer immunotherapy – a computational design approach, 42nd FEBS Conference
• 2017-07-13, Polymeric nanoparticles as cancer vaccines and immunomodulators, 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3DU Meeting
• 2017-07-13, Hybrid Lipid-Polymeric Nanoparticles for the Treatment of Melanoma by Strengthening the Host Immune Response, 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3DU Meeting
• 2017-06-20, A novel multifunctional star-shaped polypeptide-based platform as an anti-cancer immunotherapeutic approach, Gordon Research Conference “Cancer Nanotechnology - Multimodal Nano-Therapies Against Cancer”
• 2017-06-18, Polymeric nanoparticles as breast cancer vaccines and immunomodulators, GRC Cancer Nanotechnology - Multimodal Nano-Therapies Against Cancer
• 2017-04-24, A novel nanoplatform as metastatic melanoma cancer vaccine, 1st SPLC-CRS Young Scientist Meeting
• 2017-02-27, Multicomponent Nanoscale Systems for Immune Modulation Against Solid Tumors., Frontiers in Cancer Immunotherapy
• 2016-11-22, Multicomponent aliphatic polyester-based nanoparticles for antigen delivery and immune modulation against cancer disease, NanoBio&Med2016
• 2016-09-04, Computational design of a novel poly–glutamic dendrimer-based platform as an anticancer therapeutic approach, 41th FEBS Congress
• 2016-05-23, Multicomponent nanoscale systems as metastatic melanoma therapeutic cancer vaccines, UT Austin|Portugal Annual Conference
• 2014-11-10, Cork extracts induce a cytoprotective effect against H2O2 oxidative damage in SH--SY5Y cells, IV ICVS/3B´S Meeting
• 2013-03-01, Neurotensin and collagen dressings improve diabetic wound healing, Annual Meeting of Portuguese Society of Diabetology
• 2012-11-23, CB1 cannabinoid receptor can contribute to early skin aging in diabetes, CISE 2012 Conference
• 2012-10-04, Neurotensin and collagen dressings improve diabetic wound healing, 8th EASD Annual Meeting
• 2011-09-14, Neurotensin and chitosan-based dressings: a new approach for diabetic wound healing treatment, 47th EASD Annual Meeting
• 2008-10-23, Effects of natural polyphenols on angiogenesis and inflammation, XVI National Congress of Biochemistry

Provisional application for patent

• Cross-linked star-shaped self-assembled polypeptides as immunotherapies