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Universidade Lusófona

Nuno Ricardo de Almeida Saraiva

Universidade Lusófona de Humanidades e Tecnologias

p4757@ulusofona.pt

Lecturer in virology, cell and molecular biology at ECTS - ULHT, where he also develops his research projects as a member of CBiOS. Nuno is an MSc in microbiology and molecular biology (from FC, Lisbon University), and a PhD in virology and cell biology (from Imperial College, London). His main research interest is tumorigenesis, focusing on the molecular mechanisms underlying metastization. Nuno has published work in molecular virology, apoptosis, Ca2+ homeostasis, membrane proteins, cell migration and adhesion.

Habilitações Académicas

GRAUCURSOESTABELECIMENTOANO
DoutorVirology and cell biologyImperial College London2012
MestradoBiologia Molecular e GenéticaUNIVERSIDADE DE LISBOA - FACULDADE DE CIÊNCIAS2008
LicenciaturaBiologia Microbiana e GenéticaUNIVERSIDADE DE LISBOA - FACULDADE DE CIÊNCIAS2006
TIPO Descrição ANO
Artigo publicado em revista científica internacional com referee Guerreiro P. S., Corvacho E., Costa J. G., Saraiva N., (..), J. P. & Oliveira, N. G. The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel. Chemical Biology & Drug Design. 2017
Artigo publicado em revista científica internacional com referee Egea J, ..., Saraiva N, ..., Daiber A. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol 13: 94-162. 2017
Artigo publicado em revista científica internacional com referee Carrara G, Parsons M, Saraiva N*, Smith GL* (2017). Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer. Open biology 7. *denotes joint senior author 2017
Membros de comités internacionais reconhecidos Member of the management committee of the European COST action ¿An integrative action for multidisciplinary studies on cellular structural networks¿. 2016
Responsabilidade pela organização de evento científico de âmbito internacional Member of the organization and scientific committees for the International Lisbon EU-ROS meeting (COST action meeting) entitled ROS in drug discovery: from target identification to redox-based therapeutics. 2016
Capítulo de livro científico ou técnico A.S. Fernandes, N. Saraiva, and N.G. Oliveira, Redox therapeutics in breast cancer: role of SOD mimics in Redox-active therapeutics, Oxidative stress in applied basic research and clinical practice. Chapter 18, Springer International Publishing (2016), Switzerland. DOI 10.1007/978-3-319-30705-3_18. 2016
Artigo publicado em revista científica internacional com referee Silva CO, Molpeceres J, Batanero B, Fernandes AS, Saraiva N, Costa JG, Rijo P, Figueiredo IV, Faísca P, Reis CP. (2016). Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy. Therapeutic delivery 7: 521-544. 2016
Artigo publicado em revista científica internacional com referee Costa JG, Saraiva N, Guerreiro PS, Louro H, Silva MJ, Miranda JP et al. Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints. Food and chemical toxicology. 87: 65-76. 2016
Artigo publicado em revista científica internacional com referee Fernandes AS, Flórido A, Saraiva N, Cerqueira S, Ramalhete S, Cipriano M, Cabral M, Miranda J, Castro J, Costa J, Oliveira N. Role of the copper(II) complex Cu[15]pyN5 in intracellular ROS and breast cancer cell motility and invasion. Chem Biol Drug Des. 2015 Jan 20. doi: 10.1111/cbdd.12521. 2015
Livro científico ou técnico Fernandes AS, Saraiva N, Oliveira N. Chapter: Redox therapeutics in breast cancer: role of SOD mimics, in Batinic-Haberle, Reboucas, Spasojevic, St. Clair, and Warner Redox-active Therapeutics. Springer, 2015 (in press ¿ expected publication: October 2015) 2015
Prémio ou distinção relacionados com a actividade científica ou técnica Recipient of a COST Action BM1203 short-term scientific mission grant (COST-STSM-BM1203-24673) to study the impact of ROS in breast cancer cell migration and adhesion at Prof. Geoffrey Smith laboratory at the University of Cambridge. 2015
Artigo publicado em revista científica internacional com referee Carrara G, Saraiva N, Parsons M, Byrne B, L. Prole D, Taylor C, and Smith G. Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration. 2015 J. Biol. Chem., 2015 May 1;290(18):11785-801. 2015
Comunicação oral apresentada em evento científico internacional Costa J, Saraiva N, Guerreiro P, Miranda J, Castro M, Oliveira N, Fernandes A, Ochratoxin A-induced cytotoxicity and formation of ROS: effect of a manganese(III) porphyrin with superoxide dismutase mimetic activity. [S2C7]. XLV SPF Meeting. Portugal. 2015. 2015
Artigo publicado em revista científica internacional com referee Sara Rosa, V. Correia, I. Ribeiro, P. Rijo, F. Simões, N. Saraiva* and A. Fernandes*. In vitro antioxidant properties of the diterpenes Parvifloron D and 7¿-acetoxy-6ß- hydroxyroyleanone. 2015 Biomed Biopharm Res; (12) 1: , 59-67 2015
Artigo publicado em revista científica internacional com referee Mota J, Campos A, Shuwisitkul D, Saraiva N, Nicolai M. Lysozyme release from lipid-based implants. Advanced Materials Research. 2014, Advanced Materials Research, 1060, 83 2014
Comunicação oral apresentada em evento científico internacional Cerqueira S, Flórido A, Oliveira N, Fernandes A*, Saraiva N*. Implementation of in vitro techniques to assess the effect of SOD mimetics in human breast cancer cell adhesion and spread. I Jornadas CBIOS. 9-10 October 2014, Lisbon, Portugal. (*Shared senior authorship) 2014
Artigo publicado em revista científica internacional com referee Saraiva N, Prole D, Carrara G, Johnson B, Taylor W, Parsons M and Smith G. hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca 2+ entry and calpain 2. J Cell Biol. 2013. Aug 19;202(4):699-713 2013
Publicação em actas com referee conferência internacional Fernandes A S, Florido A, Cipriano M, Batinic-Haberle I, Miranda J, Saraiva N, Guerreiro P S, Castro M, Oliveira N G, Combined effect of the SOD mimic MnTnHex-2-PyP5+ and doxorubicin on the migration and invasiveness of breast cancer cells. Toxicology Letters vol. 221 August 28, 2013. p. S70-S71 2013
Artigo publicado em revista científica internacional com referee Saraiva N, Prole D, Carrara G, Maluquer de Motes C, Johnson B, Byrne B, Taylor W and Smith G. Determinants and functional Consequences of Oligomerization of Human and Viral Golgi Anti-Apoptotic Proteins (GAAPs). J Biol Chem. 2013 May 3;288(18):13057-67 2013
Artigo publicado em revista científica internacional com referee Carrara G, Saraiva N, Gubser C, Johnson B and Smith G. A six transmembrane topology for Golgi Anti-Apoptotic Protein (GAAP) and Bax Inhibitor 1 (BI-1) provides a model for the Transmembrane Bax Inhibitor Containing Motif (TMBIM) family. J Biol Chem. 2012 May 4;287(19):15896-905. 2012
Prémio ou distinção relacionados com a actividade científica ou técnica Guia Carrara, Benjamin Johnson, Nuno Saraiva and Geoffrey Smith. Mapping the transmembrane topology of Golgi Anti-Apoptotic Protein (GAAP), 2011, The Biochemical Society Annual Symposium on Recent advances in Membrane biochemistry, Cambridge. (Best poster prize) 2011
Artigo publicado em revista científica internacional com referee Cadima-Couto I1, Saraiva N1, Santos AC, Goncalves J. HIV-1 Vif Interaction with APOBEC3 Deaminases and its Characterization by a New Sensitive Assay. J Neuroimmune Pharmacol. 2011 Jan 29. (1 these authors contributed equally to the manuscript) 2011
Prémio ou distinção relacionados com a actividade científica ou técnica Award for best poster at the 2011 Biochemical Society Annual Symposium on recent advances in membrane biochemistry, Cambridge. 2011
Comunicação oral apresentada em evento científico internacional Carrara G, Saraiva N, Smith, G L, Mapping the transmembrane topology of Golgi Anti-Apoptotic Protein (GAAP), 2011. Cambridge Membrane Traffic Meeting 2011. Cambridge, UK. 2011