filmeu

Teacher
Nuno Saraiva

Nuno Saraiva
p47***@ulusofona.pt
0A16-91EA-C570
0000-0003-1333-9137

Resume

Nuno Saraiva. Completed his PhD in Cell Biology and Virology in 2012 by Imperial College London Faculty of Medicine, his MSc in Genetics and Molecular biology in 2008 by Universidade de Lisboa Faculdade de Ciências and his BSc in Microbiology and Genetics in 2006 by Universidade de Lisboa Faculdade de Ciências. Nuno developed his Post-Doc research project at the University of Cambridge, Department of Pathology, UK. He is currently an Assistant Professor at the Lusófona University and an Invited Assistant Professor at the Lisbon University Faculty of Sciences (FCUL). Nuno is a Principal investigator since 2017 at the Research Center for Biosciences & Health Technologies (CBIOS). There, he has studied the impact of intracellular Ca2+ and redox modulation/signalling on cancer progression by dissecting their role on processes such as cancer cell migration/invasion and survival/death. He has received 5 awards and/or honours. Published more than 35 full articles in international journals and one book chapter. Organised various scientific event(s) and participated on the management committee of three COST actions (EuroCellNet ERNEST and Adher´n Rise) and is part of the Net4Brain action. Supervisor of 3 PhD theses. Supervised over 15 MSc and 10 BSc dissertations, in addition to numerous undergrad students (scientific initiation) or Erasmus+ trainees.

Graus

  • Doutoramento
    Cell Biology and Virology
  • Mestrado
    Genetics and Molecular Biology
  • Licenciatura
    Microbiology and Genetics

Publicações

Pré-impressão

Artigo em revista

  • 2024-03-14, Antitumoral Activity of Cecropia Pachystachya Leaves Extract in Vitro and in Vivo Model of Rat Glioma: Brain and Blood Effects, Molecular Neurobiology
  • 2023-12-19, The Golgi Apparatus as an Anticancer Therapeutic Target, Biology
  • 2023-07-27, The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP5+, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin, Cancers
  • 2023-04-11, Mixed Edge Activators in Ibuprofen-Loaded Transfersomes: An Innovative Optimization Strategy Using Box–Behnken Factorial Design, Pharmaceutics
  • 2023, Mixed Edge Activators in Transfersomes: an Innovative Optimization, Pharmaceutics
  • 2023, Evaluation of the Lysyl Oxidase-Like 2 (LOXL2) inhibitory activity of pimaranes and their glycosyl derivatives, Journal Biomedical and Biopharmaceutical Research
  • 2022-12-15, Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes, Frontiers in Endocrinology
  • 2022-12-15, The Dietary Isothiocyanate Erucin Reduces Kidney Cell Motility by Disturbing Tubulin Polymerization, Molecular Nutrition & Food Research
  • 2022-11-07, MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells, Antioxidants
  • 2022-06-21, Lysyl Oxidases Expression and Breast Cancer Progression: A Bioinformatic Analysis, Frontiers in Pharmacology
  • 2022-06, Lysyl Oxidases Expression and Breast Cancer Progression: A Bioinformatic Analysis, Frontiers in Pharmacology
  • 2022-04-23, Impact of Portuguese propolis on keratinocyte proliferation, migration and ROS protection: significance for applications in skin products, International Journal of Cosmetic Science
  • 2022-04, GOLGI: Cancer cell fate control, The International Journal of Biochemistry & Cell Biology
  • 2021-12-31, Cecropia pachystachya protection against preproIAPP cytotoxicity is independent of Ca2+ homeostasis: lessons learned using a novel yeast model of preproIAPP-induced Ca2+ intracellular dysregulation, Journal Biomedical and Biopharmaceutical Research
  • 2021-02-19, LOXL2 Inhibitors and Breast Cancer Progression, Antioxidants
  • 2020-12, Gene expression and survival analysis in cancer research using online open access platforms: a comparative analysis, Biomedical and Biopharmaceutical Research Journal
  • 2020-06-24, Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion, Antioxidants
  • 2020-01-19, Anti-Migratory and Pro-Apoptotic Properties of Parvifloron D on Triple-Negative Breast Cancer Cells, Biomolecules
  • 2020-01, Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism, Redox Biology
  • 2020, A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells, Food and Chemical Toxicology
  • 2019-12-20, An Overview on the Properties of Ximenia Oil Used as Cosmetic in Angola, Biomolecules
  • 2019-10-17, The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells, Antioxidants
  • 2019-09-10, Contaminants: a dark side of food supplements?, Free Radical Research
  • 2019-06, Cytotoxic effect of antioxidants found in food from plant origin on human osteosarcoma U2OS Cells, Journal Biomedical and Biopharmaceutical Research
  • 2019-05-08, Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities, Biomolecules
  • 2019, The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells, Redox Biology
  • 2019, Migration and invasion of human renal cancer cells are impaired upon treatment with thymoquinone, Toxicology Letters
  • 2019, Golgi anti-apoptotic proteins are evolutionarily conserved ion channels that regulate cell death in plants, ioRxiv
  • 2018, The human Golgi anti-apoptotic protein induces cell invasion by an H2O2-dependent mechanism, Free Radical Biology and Medicine
  • 2018, European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (vol 13, pg 94, 2017), Redox Biology
  • 2018, Beneficial impact of a manganese(III) porphyrin in cancer cell migration, Free Radical Biology and Medicine
  • 2018, Anti-tumor properties of the redox-active compound Parvifloron D in breast cancer cells, Free Radical Biology and Medicine
  • 2017-12, Cytotoxicity of N-nitrosoguanidines in a breast cancer cell model, Journal Biomedical and Biopharmaceutical Research
  • 2017, Viability and migration of human renal cancer cells upon treatment with a superoxide dismutase mimic, Toxicology Letters
  • 2017, The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel, Chemical Biology and Drug Design
  • 2017, Golgi anti-apoptotic protein: A tale of camels, calcium, channels and cancer, Open Biology
  • 2017, Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162], Redox Biology
  • 2017, Choline- versus imidazole-based ionic liquids as functional ingredients in topical delivery systems: cytotoxicity, solubility, and skin permeation studies, Drug Development and Industrial Pharmacy
  • 2016-12, Xanthine Oxidase Inhibitory Activity of a Plectranthus saccatus aqueous extract, Journal Biomedical and Biopharmaceutical Research
  • 2016, Redox Therapeutics in Breast Cancer: Role of SOD Mimics, Studies on Retinal and Choroidal Disorders
  • 2016, Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints, Food and Chemical Toxicology
  • 2016, Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy, Therapeutic Delivery
  • 2015, Role of the Copper(II) Complex Cu[15]pyN 5 in Intracellular ROS and Breast Cancer Cell Motility and Invasion, Chemical Biology & Drug Design
  • 2015, Ionic liquids as solubility/permeation enhancers for topical formulations: Skin permeation and cytotoxicity characterization, Toxicology Letters
  • 2015, Impact of the SOD mimic MnTnHex-2-PyP on the adhesion and migration of doxorubicin-treated MDA-MB-231 cells, Toxicology Letters
  • 2015, Golgi Anti-apoptotic Proteins Are Highly Conserved Ion Channels That Affect Apoptosis and Cell Migration, Journal of Biological Chemistry
  • 2015, Effect of the SOD mimetic MnTnHex-2-PyP on the generation of ROS and cytotoxicity induced by ochratoxin A, Toxicology Letters
  • 2015, Cytotoxicity screening of Plectranthus spp. extracts and individual components in MDA-MB-231 cells, Toxicology Letters
  • 2014, Effect of Cu[15]pyN(5) on MDA-MB-231 cell migration and invasion, Toxicology Letters
  • 2014, Abietane diterpenes from Plectranthus madagascariensis: A cytotoxicity screening, Planta Medica
  • 2013-06, CBiOS Science Sessions - 2013, Journal Biomedical and Biopharmaceutical Research
  • 2013, hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca 2+ entry and calpain 2, The Journal of Cell Biology
  • 2013, Human and viral golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium, Journal of Biological Chemistry
  • 2013, Combined effect of the SOD mimic MnTnHex-2-PyP5+ and doxorubicin on the migration and invasiveness of breast cancer cells, Toxicology Letters
  • 2012, Six-transmembrane Topology for Golgi Anti-apoptotic Protein (GAAP) and Bax Inhibitor 1 (BI-1) Provides Model for the Transmembrane Bax Inhibitor-containing Motif (TMBIM) Family, Journal of Biological Chemistry
  • 2011, HIV-1 Vif Interaction with APOBEC3 Deaminases and its Characterization by a New Sensitive Assay, Journal of NeuroImmune Pharmacology

Tese / Dissertação

  • 2012-02-13, Doutoramento, Biochemical and Functional Characterization of Golgi Anti- Apoptotic Proteins (GAAP)
  • 2007, Mestrado, Relação estrutura/função das proteínas da família APOBEC e sua interacção com a proteína Vif do HIV-1

Artigo em jornal

  • 2021-12-08, Respostas em ciência: as boas, as más e as vilãs, SOL

Entrada de enciclopédia

  • Fernandes, A.S. The Golgi Apparatus as an Anticancer Therapeutic Target, Encyclopedia

Resumo em conferência

  • 2023-11-10, The TMBIM4 Golgi ion channel shapes cancer cell survival by modulating metabolic pathways, V Jornadas CBIOS
  • 2023-11-10, Exploring the impact of TMBIM Proteins on glioma: insights from tumour expression patterns and cellular functional studies, V Jornadas CBIOS
  • 2023-03-14, The food bioactive erucin impacts on kidney cells migration mechanisms., 2nd International Meeting of the Portuguese Physiological Society
  • 2023-03-14, The cis isomer of the skin chromophore urocanic acid decreases keratinocytes viability and collective migration, 2nd International Meeting of the Portuguese Physiological Society
  • 2022-07-14, Simultaneous expression dysregulation of redox and calcium signalling-related genes: impact on breast cancer patient survival, FEBS
  • 2022-07-14, Lysyl oxidase like 2 as a therapeutic target for breast cancer: bioinformatics analysis and biochemical evaluation of 4-thiazolidinone derivatives, FEBS
  • 2022-07, The ion channel transmembrane BAX inhibitormotif-containing 4 promotes glioblastoma cell invasion, IUBMB FEBS PABMB Congress, The Biochemistry Global Summit
  • 2018-10-08, Choline-based ionic liquids to deliver poorly soluble drugs in topical delivery systems, 27th EuCheMSil
  • 2017-07, Ionic liquids as functional ingredientes in drug delivery systems, Encontro Ciência 2017
  • 2016-10, Functional Ingredients in delivery systems, II Scientific Conferences CBIOS

Poster em conferência

  • 2024-02-14, May TransfersomILs redefine the hydroxycinnamic acids delivery to the skin?, XV Spanish-Portuguese Conference on Controlled Drug Delivery
  • 2024-02-14, Lipid extract from larvae biomass: an added-value biomaterial to produce lipid nanoparticles to tackle atopic dermatitis, XV Spanish-Portuguese Conference on Controlled Drug Delivery
  • 2024-02-14, Cerosomes at the forefront: a multifunctional strategy for addressing Xeroderma Pigmentosum, XV Spanish-Portuguese Conference on Controlled Drug Delivery
  • 2023-10-26, The Role of Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) Intracellular Ion Channels in Glioma, III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumour Microenvironment and Metastasis
  • 2023-10-26, The Golgi ion channel TMBIM4 controls cancer cell invasion and survival via modulation of the transsulfuration pathway, III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumour Microenvironment and Metastasis
  • 2023-07-06, Role of the Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) gene in glioma: impact in tumour progression, Encontro com a Ciência e a Tecnologia em Portugal
  • 2023-07-05, Using insect larvae biomass to produce innovative lipid nanoparticles: a bioinspired and sustainable approach to tackle atopic dermatitis, Ciência 2023
  • 2023-06-19, TransfersomILs: an innovative nanosystem for the cutaneous delivery of hydroxycinnamic acids, NanoMed Europe 2023
  • 2023-06-19, From insect larvae biomass to lipid-based nanocarriers: an advanced approach for the management of atopic dermatitis., NanoMed Europe 2023
  • 2023-06-19, Combining lipids extracted from larvae biomass and biobased ionic liquids to boost skin nanodelivery, NanoMed Europe 2023
  • 2023-02-06, Exploring the innovative TransfersomILs for the cutaneous delivery of hydroxycinnamic acids, 4th SPLC-CRS Young Scientists Meeting
  • 2022-11-11, Probing the impact of TransferomILs containing rutin in skin physiology ¿ cytotoxicity studies, 2nd International Meeting of the Portuguese Society of Physiology
  • 2022-11-11, Overcoming the skin barrier- Optimization of Ibuprofen-loaded Transfersomes for Transdermal Delivery, 2nd International meeting of the Portuguese Society of Physiology
  • 2022-11-11, New perspectives in the approach to skin barrier dysfunction - using lipid nanoparticles based on insect biomass to improve dexamethasone delivery, 2nd International Meeting of the Portuguese Society of Physiology
  • 2022-07-14, Expression profile of cellular redox and calcium signalling-related genes: role in breast cancer progression., The Biochemistry Global Summit, Lisbon 2022
  • 2021-10-14, Lysyl Oxidases in the pathophysiology of breast cancer: a bioinformatics approach, 56º Congresso Anual da SBFIS Online
  • 2021-10-07, Bioinformatics analysis for Lysyl Oxidases as therapeutic targets for breast cancer., Molecular Analysis for Precision Oncology Virtual Congress 2021
  • 2021-09-24, Lisil Oxidases como possíveis alvos terapêuticos para o cancro da mama: análise baseada na bioinformática., 3º Encontro Nacional de Jovens Investigadores em Oncologia. Congresso Híbrido.
  • 2021-06-11, Contribution of TMBIM family members to glioblastoma progression, Innovative Cancer Science: Better Outcomes Through Research, 27th Congress of the European Association for Cancer Research (EACR)
  • 2021-06, Increased cytotoxicity and impairment of cell migration and invasion by E3330 in cisplatin-treated NSCLC cells, iMed.ULisboa meeting 2021
  • 2021-03-24, Influence of TMBIM family members in glioblastoma cell invasion, EuroCellNet Cost Training School: New technological tools for the study of cytoplasmic intermediate filaments in the central nervous system in health and disease
  • 2020-11-23, Overexpression of the Golgi protein hGAAP/TMBIM4 promotes cell survival, IV Jornadas CBIOS: There is research beyond COVID-19
  • 2020-09-25, Effect of TMBIM family members in glioma. , Cancer Biology: From Basic to Translation Research - promoted by ASPIC and Liga Portuguesa Contra o Cancro
  • 2020-01, Ionic liquids as a strategy to improve drug delivery systems, 13º Encontro Nacional de Química Orgânica / 6º Encontro Nacional de Química Terapêutica
  • 2019-10-03, Effects of the food bioactive erucun on human renal cancer cells, COST Action CA 16112 _ NutRedOx Meeting
  • 2019-09-27, Impact of the food bioactive erucin on human renal cancer cells, I Bio.Natural
  • 2019-09, Migration and Invasion of human renal cancer cells is impaired upon treatment with thymoquinone, EUROTOX 2019 - 55th Congress of the European Societies of Toxicology
  • 2019-07-15, Impact of E3330 in Non-Small Cell Lung Cancer Cells Viability and Migration Upon Cisplatin Treatment, 11th iMed.ULisboa Postgraduate & 4th i3DU Students Meeting
  • 2019-02-25, Ionic liquids in drug delivery, COST CA17103 - Delivery of Antisense RNA Therapeutics
  • 2016-10, Amino acid based ionic liquids as functional ingredients in topical formulations containing caffeine, II Scientific Conferences CBIOS
  • 2015-07, Ionic liquids as solubility/permeation enhancers for topical drug delivery systems, 19th European Symposium of Organic Chemistry
  • 2015-07, Evaluation of an inhibitor of APE1 redox function in docetaxel-treated MDA-MB-231 cells., 7th iMed.ULisboa Postgraduate Students Meeting
  • 2014-11, Cytotoxicity, genotoxicity and reactive oxygen species production by ochratoxin A in monkey kidney cells, II Jornadas Ibéricas de Toxicologia
  • 2014-10, Ionic liquids as functional ingredients in topical drug delivery systems, Ist Scientific Conferences CBIOS
  • 2014-09, Cytotoxicity, genotoxicity and ROS production by ochratoxin A in Vero cells, Summer School ¿Biochemical Basis of Healthy Aging

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