Vera Mónica Sousa Isca

Vera Mónica Sousa Isca


Currently a PhD student at the PhD Program in Pharmacy in Faculdade de Farmácia da Universidade de Lisboa and hosted in the CBIOS - Universidade Lusófona de Humanidades e Tecnologias, financed by FCT. BS in Biochemistry from the University of Beira Interior, in 2010 and MS in Organic Chemistry and Natural Products from the University of Aveiro in 2013. Laboratory skills in Organic Chemistry, Phytochemistry, Spectroscopic and Separation Technics acquired in investigation projects from July 2017 to December 2018 financed from three FCT investigation grants. Know-how in molecular docking acquired in a training school in Tenerife, Spain, on December 2018 and consolidated in an STSM in Siena, Italy, in February-March 2019 financed by COST action CM 1407. Co-author of several international journal articles, reviews and papers with referees, co-author of a book chapter in the book: Natural Products: Research Reviews. (2012) Vol. 2, p. 145-76. Professor of laboratorial classes of Inorganic Medicinal Chemistry and monitor of project and master thesis for students in the laboratory.


  • Licenciatura
  • Mestrado
    Química, ramo de Química Orgânica e Produtos Naturais
  • Doutoramento


Artigo em revista

  • 2021-09-16, Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents, ChemMedChem
  • 2021-06, Rebound increases in chemokines by CXCR2 antagonist in breast cancer can be prevented by PKCd and PKCe activators, Cytokine
  • 2021-06, General Toxicity screening of Royleanone derivatives using an Artemia salina model, Journal Biomedical and Biopharmaceutical Research
  • 2021-05-18, Preliminary Phytochemical Analysis and Evaluation of the Biological Activity of Leonotis nepetifolia (L.) R. Br Transformed Roots Extracts Obtained through Rhizobium rhizogenes-Mediated Transformation, Cells
  • 2020-11-30, Phytochemical and Pharmacological Study of Plectranthus ecklonii Benth, Proceedings
  • 2020-11-17, Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors, Frontiers in Pharmacology
  • 2020-11-05, Updated review of the bioactive compounds isolated from Plectranthus ecklonii Benth, Proceedings of 6th International Electronic Conference on Medicinal Chemistry
  • 2020-11-05, Self-assembly nanoparticles of 7a-acetoxy-6ß-hydroxyroyleanone isolated from Plectranthus hadiensis, Proceedings of 6th International Electronic Conference on Medicinal Chemistry
  • 2020-06-16, Diterpenoids from Plectranthus spp. as Potential Chemotherapeutic Agents via Apoptosis, Pharmaceuticals
  • 2020-05-23, Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones, International Journal of Molecular Sciences
  • 2020-04-06, Artemia species: An important tool to screen general toxicity samples, Current Pharmaceutical Design
  • 2020-04, Diterpenoids from edible Plectranthus spp. as potential chemopreventive and therapeutic agents in cancer, Proceedings of III Jornadas Lusófonas da Nutrição, Biomedical and Biopharmaceutical Research Journal
  • 2020-03-16, Molecular Docking Studies of Royleanone Diterpenoids from Plectranthus spp. as P-Glycoprotein Inhibitors, ACS Medicinal Chemistry Letters
  • 2019-11-12, Optimization extraction study for the isolation of a bioactive diterpene from Plectranthuns ornatus Codd., Proceedings of 5th International Electronic Conference on Medicinal Chemistry
  • 2019-10-30, Design and molecular docking studies of new potential PKC-d activators based on royleanone scaffold, Proceedings of 5th International Electronic Conference on Medicinal Chemistry
  • 2019-10-30, Cytotoxic activity of coleon diterpenoids from Plectranthus mutabilis codd., Proceedings of 5th International Electronic Conference on Medicinal Chemistry
  • 2019-02-15, Cytotoxic Stilbenes and Derivatives as Promising Antimitotic Leads for Cancer Therapy, Current Pharmaceutical Design
  • 2019, Naphthoylhydrazones: coordination to metal ions and biological screening, New Journal of Chemistry
  • 2018-06-05, Direct synthesis of a-aminophosphonates from biomass resources catalyzed by HReO4 , Green Chemistry
  • 2018, Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity, Arabian Journal of Chemistry
  • 2015, Saliramophenol, an unprecedented natural t-butylphenol derivative from Salicornia ramosissima J. Woods, RSC Advances
  • 2014, Lipophilic profile of the edible halophyte Salicornia ramosissima, Food Chemistry

Tese / Dissertação

  • 2013, Mestrado, Salicornia ramosissima J. Woods: estudo fitoquímico das partes aéreas

Capítulo de livro

  • An overview of Salicornia genus : the phytochemical and pharmacological profile, Daya Publishing House

Artigo em conferência

  • Salicornia ramosissima: secondary metabolites and testicular protection induced by ethanol extract
  • Salicornia ramosissima an edible halophyte with nutritional value and a source of a unique natural compound
  • Compounds identified on hexane and dichloromethane extracts of Salicornia ramosissima

Resumo em conferência

  • 2021-11-02, Inhibition of P-glycoprotein activity to overcome multidrug resistance in cancer with new diterpene royleanones from Plectranthus spp.
  • 2020-12, Natural Cytotoxic Diterpenoids as a Potential Source of Drug Leads for cancer Therapy
  • 2020-11-05, Insight into P-glycoprotein activity of royleanones from Plectranthus spp.
  • 2020-11-05, Chemical Composition and Biological Activity of Diterpenoids from Plectranthus mutabilis
  • 2019-12, Molecular docking as a tool to design new royleanone derivatives for colon cancer therapy based on PKC-d modulation
  • 2019-12, Bio-guided phytochemical study of Plectranthus mutabilis Codd.

Poster em conferência

  • 2018-11-08, Bio-guided fractionation and isolation study of bioactive components from Plectranthus mutabilis Codd., 1ª Conferência sobre Investigação em Produtos Naturais e Avícolas – Iniciativa conjunta CBIOS-CYTED, Lisbon
  • 2018-10-04, In vitro antimicrobial and cytotoxic activity of natural and hemi-synthetic isopimaranes, III CBIOS Seminar, Lisbon
  • 2018-07-24, Isopimarane-type diterpenoids - In vitro antimicrobial activity, 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting, Lisbon
  • 2018-06-27, In vitro antimicrobial activity of isopimarane-type diterpenoids , Chemistry at ULisboa & 2018 Summer School – 3rd Meeting of the College of Chemistry, Lisbon
  • 2012, Some aromatic compounds from dichloromethane extract of Salicornia ramosissima


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