Docente
Bernardo José Espadinha De Brito Palma

Resume

Bernardo Brito Palma has a PhD in Molecular Toxicology. He is Assistant Professor at Escola de Ciências e Tecnologias da Saúde (ECTS), Universidade Lusófona. He's responsible for the subject of Genetics in the degree of Nutrition Sciences and for the subjects of Human Genetics and Clinical Biochemistry for Pharmaceutical Sciences Master degree. He is a Research colaborator at Center for Biosciences & Health Technologies (CBIOS). He also exerts functions in the dinamization and development of the knowledge transfer center (KTC) at the ECTS.

Graus

• Doutoramento
  Chemistry and Pharmaceutical Sciences, Molecular Toxicology
• Licenciatura
  Licenciatura em Bioquímica
• Outros
  CAP - Curso de Aptidão Profissional
• Outros
  A Norma NP EN ISO/IEC 17025:2018
• Outros
  Drug Disposition & Safety Assessment
• Pós-Graduação
  Introdução à Toxicologia
• Outros
  Formação de Liderança em Segurança, Valores e Crenças
• Outros
  Saber E´STAR em Segurança - Formação de Formadores
• Outros
  High-throughput (HT) Drug Metabolism/Disposition

Publicações

Journal article

• 2018-12-06, Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450., International journal of molecular sciences
• 2016-06-18, Cytochrome P450 expression system for high-throughput real-time detection of genotoxicity: Application to the study of human CYP1A2 variants., Mutation research. Genetic toxicology and environmental mutagenesis
• 2016-04-14, Prototype Systems Containing Human Cytochrome P450 for High-Throughput Real-Time Detection of DNA Damage by Compounds That Form DNA-Reactive Metabolites., Chemical research in toxicology
• 2013-02-01, Functional characterization of eight human CYP1A2 variants: the role of cytochrome b5., Pharmacogenetics and genomics
• 2010-07-01, Alkylating potential of oxetanes., Chemical research in toxicology
• 2010-02-02, Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression., The pharmacogenomics journal
• 2006-12-08, The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450-mediated biotransformation (a corrigendum report on Duarte et al. (2005) Mutagenesis 20, 93-100)., Mutagenesis
• 2005-04-20, Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines., Mutagenesis
• 2005-02-22, The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation., Mutagenesis

Thesis / Dissertation

• 2017-10-16, PhD, Development of Human Cytochrome P450 Competent Genotoxicity Tester Bacterial Systems for High Throughput Screening - Functional Characterization of Human Cytochrome P450 1A2 Polymorphic Variants
• 2003-10-14, Degree, Development of new bacteria strains to study xenobiotics biotransformation: Coexpression of Human Cytchrome b5, Cytchrome P450 and NADPHCytchrome P450 reductase, to use in mutagenicity assays

Book

• 2021, Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0, {MDPI

Conference paper

• 2005-01-01, The role of protein-protein interactions in the stimulation of the bioactivation of mutagens by CYP1A2, 2A6 and 2E1 in the presence of cytochrome b5: A new cell system to study the cytochrome P450 mediated biotransformation, 14th International Conference on Cytochromes P450: Biochemistry, Biophysics, and Bioinformatics

Conference poster

• 2020-09-12, Brito Palma, B.; Rueff, J.; Kranendonk, M.; "Prototype Systems Containing Human Cytochrome P450 For High-Throughput Real-Time Detection of Genotoxicity", Environmental Mutagenesis & Genomics Society Virtual Annual Meeting
• 2019-09-08, Brito Palma, B.; Sardo, I.; Pires, C.; Costa, J.; Palma, D.; Martins, C.; "Comparison of negative control historic data of the Bacterial Reverse Mutation Test (Ames Test): Implications in assays acceptance and results evaluation.", 55th Congress of the European Societies of Toxicology (EUROTOX 2019)
• 2017-10-02, Brito Palma, B.; Kranendonk, M.; "Development of Human Cytochrome P450 Competent Genotoxicity Tester Bacterial Systems for High Throughput Screening - Functional Characterization of Human Cytochrome P450 1A2 Polymorphic Variants", 3rd Genetics Workshop NOVA Health, Universidade NOVA de Lisboa
• 2016-05-14, Brito Palma, B.; Kranendonk, M.; "Human Cytochrome P450 competent High-Throughput Test for the Detection of Genotoxic/Electrophilic Reactive Metabolites", 1st NOVA Biomedical Engineering Workshop
• 2015-10-09, Brito Palma, B.; Kranendonk, M.; "Prototype Development of Human Cytochrome P450 competent High Throughput Test for the Detection of Genotoxic/Electrophilic Reactive Metabolites", 1st Genetics Workshop NOVA Health
• 2015-09-28, Brito Palma, B.; Kranendonk, M.; "Prototype Development of Human Cytochrome P450 competent High Throughput Test for the Detection of Genotoxic/Electrophilic Reactive Metabolites", Centre for Toxicogenomics and Human Health (ToxOmics) Scientific Meeting
• 2012-06-17, Brito Palma, B.; Silva e Sousa, M.; Urban, P.; Rueff, J.; Kranendonk, M.; "Functional Characterization Of Eight Human CYP1A2 Variants: The Role Of Cytochrome b5", 19th International Symposium on Microsomes and Drug Oxidations / 12th European Regional ISSX Meeting
• 2009-05-17, Brito Palma, B.; Silva e Sousa, M.; Lastdrager, J.; Rueff, J.; Vermeulen, N.P.E.; Kranendonk, M.; "Human Cytochrome P450 1A2: Comprehensive Study of Eight Polymorphic Variants", 11th European Regional ISSX Meeting
• 2005-01-01, Kranendonk, M.; Duarte, M.P.; Brito Palma, B.; Gilep, A.A.; Oliveira, J.S.; Usanov, S.A.; Rueff, J.; "The role of protein-protein interactions in the stimulation of the bioactivation of mutagens by CYP1A2, 2A6 and 2E1 in the presence of cytochrome b5: A new cell system to study the cytochrome P450 mediated biotransformation.", 14t h International Conference on Cytochromes P450: Biochemistry, Biophysics, and Bioinformatics
• 2004-07-04, Duarte, M.P.; Brito Palma, B.; Laires, A.; Oliveira, J.S.; Rueff, J.; Kranendonk, M.; "The stimulatory role of human cytochrome B5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: A new cell-system for the study of human 12 cytochrome P450 mediated biotransformation", 15th International Symposium on Microssomes and Drug Oxidations
• 2003-04-27, Duarte, M.P.; Brito Palma, B.; Laires, A.; Oliveira, J.S.; Rueff, J.; Kranendonk, M.; "BTC, a Human P450 containing Escherichia coli Tester Strain with a High Sensitivity towards Alkylating Agents", 8th International Society for Study of Xenobiotics (ISSX)