Docente
João G. Costa

Resume

João Guilherme Costa holds a PhD in Experimental and Clinical Pharmacy (Health Sciences), from the University of Alcalá de Henares, 2018. He completed the Integrated Master in Pharmaceutical Sciences at the Faculty of Pharmacy, University of Lisbon (FFUL) in 2008 and, obtained a Specialization in Quality Control and Food Toxicology (FFUL, 2013). João is an Assistant Professor at the School of Health Sciences and Technologies (ECTS), Lusófona University since 2013, teaching disciplines in the areas of Pharmacology and Toxicology. João is a researcher and integrated member of CBIOS and a collaborator of iMed.UL-FFUL. João is member of the Lusófona University and ECTS Ethics Committees and member of the Scientific Councils of ECTS and CBIOS. He published more than 35 full articles in international journals and 4 book chapters, and received 15 awards/distinctions for his scientific research. He has several communications at national and international scientific congresses. João is currently supervising 1 PhD thesis and 5 MPharm dissertations. He is a member of the Editorial Board of the Foods journal and is a reviewer of several international journals in the area of Health Sciences. He participated in the organization of various scientific events. His lines of research include the study of potential new drugs, being mainly related to the areas of oxidative stress and cancer.

Graus

• Mestrado
  Integrated Master in Pharmaceutical Sciences
• Curso de mestrado (conclusão do curso de especialização)
  Specialization / Post-Graduation in Quality Control and Food Toxicology
• Doutoramento
  Experimental and Clinical Pharmacy (Health Sciences)
• Outros
  Advanced Training Course in Clinical Trials Monitoring

Publicações

Journal article

• 2024-12-31, Analysis of food supplements and sports foods consumption patterns among a sample of gym-goers in Portugal, Journal of the International Society of Sports Nutrition
• 2024-07-23, Assessing knowledge and awareness of Food and Drug Interactions among nutrition sciences students: Implications for education and clinical practice, Nutrition and Health
• 2024-07, Exploring the feasibility and implications of cranioencephalic computed tomography in HER2-positive breast cancer: A pilot study, Heliyon
• 2024-05-20, Editorial: Education in pharmacology of anti-cancer drugs: 2023, Frontiers in Pharmacology
• 2023-07-27, The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP5+, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin, Cancers
• 2023-07-19, Functional Foods for Health: The Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables and Culinary Herbs, Foods
• 2023-07, Anthracyclines versus No Anthracyclines in the Neoadjuvant Strategy for HER2+ Breast Cancer: Real-World Evidence, Clinical Drug Investigation
• 2023-02, The Dietary Isothiocyanate Erucin Reduces Kidney Cell Motility by Disturbing Tubulin Polymerization, Molecular Nutrition & Food Research
• 2023, Food Contact Materials: contaminants and associated risks from the reports published in the RASFF portal (2020-2022), Biomedical and Biopharmaceutical Research
• 2023, Evaluation of the Lysyl Oxidase-Like 2 (LOXL2) inhibitory activity of pimaranes and their glycosyl derivatives, Journal Biomedical and Biopharmaceutical Research
• 2022-11-07, MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells, Antioxidants
• 2022-08-03, Tumor-infiltrating lymphocytes in early breast cancer: an exploratory analysis focused on HER2+ subtype in Portuguese patients, Current Medical Research and Opinion
• 2022-04, Polyphenols and Their Metabolites in Renal Diseases: An Overview, Foods
• 2021-12-21, TransfersomILs: From Ionic Liquids to a New Class of Nanovesicular Systems, Nanomaterials
• 2021-06, A narrative review of the migration and invasion features of non-small cell lung cancer cells upon xenobiotic exposure: insights from in vitro studies, Translational Lung Cancer Research
• 2021-04-21, Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool, International Journal of Molecular Sciences
• 2021-04, Systemic treatment of HER2-positive breast cancer patients with brain metastases: current status and exploratory case study in a Portuguese cohort, Journal Biomedical and Biopharmaceutical Research
• 2020-10-05, (Bio)Technological aspects of microalgae pigments for cosmetics, Applied Microbiology and Biotechnology
• 2020-06-24, Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion, Antioxidants
• 2020-03, In vitro cytotoxicity assessment of ferulic, caffeic and p-coumaric acids on human renal cancer cells, Biomedical and Biopharmaceutical Research Journal
• 2020-02-04, Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells, Biomolecules
• 2020-02, A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells, Food and Chemical Toxicology
• 2020-01-19, Anti-Migratory and Pro-Apoptotic Properties of Parvifloron D on Triple-Negative Breast Cancer Cells, Biomolecules
• 2019-10-17, The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells, Antioxidants
• 2019-09-10, Contaminants: a dark side of food supplements?, Free Radical Research
• 2019-06, Cytotoxic effect of antioxidants found in food from plant origin on human osteosarcoma U2OS Cells, Journal Biomedical and Biopharmaceutical Research
• 2019, The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells, Redox Biology
• 2019, Migration and invasion of human renal cancer cells are impaired upon treatment with thymoquinone, Toxicology Letters
• 2018-12, Choline-Amino Acid Ionic Liquids as Green Functional Excipients to Enhance Drug Solubility, Pharmaceutics
• 2017-12, Cytotoxicity of N-nitrosoguanidines in a breast cancer cell model, Journal Biomedical and Biopharmaceutical Research
• 2017, The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel, Chemical Biology and Drug Design
• 2017, European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS), Redox Biology
• 2016-12, Xanthine Oxidase Inhibitory Activity of a Plectranthus saccatus aqueous extract, Journal Biomedical and Biopharmaceutical Research
• 2016, Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1, Chemical Biology and Drug Design
• 2016, Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints, Food and Chemical Toxicology
• 2016, Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy, Therapeutic Delivery
• 2013, Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxicity in MDA-MB-231 human breast cancer cells, Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Book chapter

• 2024, Micotoxinas, Toxicologia Alimentar, Lidel
• 2021, Fruit and vegetable juices and Breast Cancer, Cancer: Oxidative Stress and Dietary Antioxidants, 2nd, Elsevier - Academic Press
• 2020, Cosmetic Applications, Microalgae - Cultivation, Recovery of Compounds and Applications, 1st, Elsevier - Academic Press
• 2018, Toxicodinâmica, Toxicologia Fundamental, LIDEL, Edições Técnicas, Lda.

Encyclopedia entry

• Polyphenols in Renal Pathophysiology, Scholarly Community Encyclopedia

Online resource

• 2023, Ionic liquids: game changers for the development of controlled delivery systems?, https://doi.org/10.3390/ECMC2023-15581

Conference abstract

• 2023, The food bioactive erucin impacts on kidney cells migration mechanisms, 2nd International Meeting of the Portuguese Society of Physiology
• 2023, The cis isomer of the skin chromophore urocanic acid decreases keratinocytes viability and collective migration, 2nd International Meeting of the Portuguese Society of Physiology
• 2023, The Portuguese physiology roadmap from molecules to the individual – perspectives from CBIOS, 2nd International Meeting of the Portuguese Society of Physiology
• 2023, Targeting Lysyl Oxidase Like 2 to prevent breast cancer metastases, Acta Farmacêutica Portuguesa, X Congresso Iberoamericano de Ciências Farmacêuticas
• 2023, Recreational Athletes’ Perception of Contaminants in Food Supplements and their Risks for Health, Acta Farmacêutica Portuguesa, X Congresso Iberoamericano de Ciências Farmacêuticas
• 2023, Lysyl Oxidase Like 2: an enzyme at the crossroad of Toxicology and Pharmacology
• 2023, Ionic liquids: game changers for the development of controlled delivery systems?
• 2023, Cell migration in health and disease: research @CBIOS, 2nd International Meeting of the Portuguese Society of Physiology
• 2023, A Brain Relapse in HER2-Positive Breast Cancer After Neoadjuvant Treatment: An International Multicentric Study
• 2022, TransfersomILs: an innovative combination between Transfersomes and Ionic Liquids, I Lusophone Meeting on Innovative Delivery Systems
• 2022, O/W emulsions containing glycinate-based ILs and phenolic compounds, I Lusophone Meeting on Innovative Delivery Systems
• 2022, Cytotoxic effects of the SOD mimic MnTnHex-2-PyP5+ and its combination with cisplatin in non-small cell lung cancer cells
• 2022, Anthracycline versus no anthracycline neoadjuvant therapy for HER2 breast cancer: real world evidence, 13th European Breast Cancer Conference (EBCC-13)
• 2021, The evaluation of tumor-infiltrating lymphocytes (TILs) in early breast cancer: differences between histologic subtypes in a Portuguese cohort
• 2021, Post neoadjuvant HER2 treatment: real world data from a multicentric cohort
• 2021, Mechanisms of resistance to trastuzumab and pertuzumab in HER2-positive breast cancer: preliminary analysis of redox and immune-related biomarkers, CBIOS Science Sessions 2021
• 2021, Glycine-based IL to improve the performance of O/W emulsions containing rutin, Fascination of Plants Day Event
• 2020, The effect of phenolic compounds on human renal cancer cells and the potential combination with ionic liquids, IV CBIOS Seminar
• 2020, In vitro anticancer activity of phenolic bioactive compounds studied in a human renal cancer cell model - Supplement III Lusófona’s Nutrition Meeting
• 2020, Brain metastases as first local of recurrence after neoadjuvant treatment in HER2 breast cancer patients: results from a multicentric cohort, IV CBIOS Seminar
• 2019-10-10, Migration and invasion of human renal cancer cells are impaired upon treatment with thymoquinone, Toxicology Letters 2019; 314
• 2019, Redox Regulation of Breast Cancer Progression: insights from SOD mimics, Physioma 2019 - 1st International Meeting of the Portuguese Society of Physiology
• 2019, MnTnHex-2-PyP, a SOD mimic as a mechanistic tool to study renal cancer pathophysiology, Physioma 2019 - 1st International Meeting of the Portuguese Society of Physiology
• 2019, In vitro safety assessment of rutin, of a choline-based ionic liquid and of their combination in renal cells, I Bioactive Natural Products Research Meeting
• 2019, Anticancer effects of erucin on human renal cancer cells, CBIOS Science Sessions
• 2018-10-08, Choline-based ionic liquids to deliver poorly soluble drugs in topical delivery systems, 27th EuCheMS Conference on Molten Salts and Ionic Liquids
• 2018-10-04, Choline-amino acid ionic liquids as green functional excipients for topical delivery of poorly soluble drugs, III CBIOS Seminar
• 2018, Impact of a Superoxide dismutase mimic in cancer cell migration, III CBIOS Seminar
• 2018, Effect of antioxidants from vegetables and fruits on Human Osteosarcoma U2-OS Cells, III CBIOS Seminar
• 2018, Cytotoxic effects of the dietary compound thymoquinone in human renal cancer cells, Biomedical and Biopharmaceutical Research 2018; 15(2)
• 2018, Beneficial impact of a manganese(III) porphyrin in cancer cell migration
• 2018, Anticancer effects of erucin on human renal cancer cells, CBIOS Science Sessions
• 2018, Anti-tumor properties of the redox-active compound Parvifloron D in breast cancer cells, III CBIOS Seminar
• 2017, Viability and migration of human renal cancer cells upon treatment with a superoxide dismutase mimic
• 2015, Targeting APE1 redox function with E3330: Effects on the migration of MDA-MB-231 cells
• 2015, Redox modulation by SOD mimics in renal cancer: from etiology to progression, CBIOS Science Sessions
• 2015, Ionic liquids as solubility/permeation enhancers for topical formulations: Skin permeation and cytotoxicity characterization
• 2015, Hybrid nanoparticles for photodynamic and targeted cancer therapy: Cytotoxicity studies
• 2015, Effect of the SOD mimetic MnTnHex-2-PyP on the generation of ROS and cytotoxicity induced by ochratoxin A
• 2015, Cytotoxicity screening of Plectranthus spp. extracts and individual components in MDA-MB-231 cells
• 2014-09-10, Effect of Cu[15]pyN5 on MDA-MB-231 cell migration and invasion., 50th Congress of the European Societies of Toxicology (EUROTOX)
• 2013, Induction of micronuclei and cytotoxic effects of ochratoxin A in Vero cells
• 2013, Effect of APE1 inhibitors on the cytotoxicity and genotoxicity of doxorubicin in MDA-MB-231 cells