Docente

João Guilherme Feliciano Da Costa

Resume

João Guilherme Costa completed the Integrated Master in Pharmaceutical Sciences at the Faculty of Pharmacy, University of Lisbon (FFUL) in 2008. He achieved a Specialization in Quality Control and Food Toxicology at FFUL in 2013. He holds a PhD in Health Sciences, in the speciality of Experimental and Clinical Pharmacy, from the University of Alcalá de Henares, 2018. João is an Assistant Professor at the School of Health Sciences and Technologies (ECTS), Lusófona University since 2013, teaching disciplines in the areas of Pharmacology and Toxicology. João is researcher and integrated member of CBIOS and a collaborator of iMed.UL-FFUL. João is member of the Lusófona University and ECTS Ethics Committees and member of the Scientific Councils of ECTS and CBIOS. He published more than 40 full articles in international journals and 4 book chapters, and received 12 awards/distinctions from his scientific research. He has several communications at national and international scientific congresses. João is currently supervising 2 PhD thesis, 1 Master thesis and 7 MPharm dissertations. He participated in the organization of various scientific events. He is also a reviewer of several international journals, namely in the areas of Toxicology and Health Sciences. His lines of research include the study of potential new drugs, being mainly related to the areas of oxidative stress and cancer.

Graus

• Mestrado
  Integrated Master in Pharmaceutical Sciences
• Curso de mestrado (conclusão do curso de especialização)
  Specialization / Post-Graduation in Quality Control and Food Toxicology
• Doutoramento
  Health Sciences – Experimental and Clinical Pharmacy
• Outros
  Advanced Training Course in Clinical Trials Monitoring

Publicações

Conference abstract

• 2023-12, Assessing Recreational Athletes' Awareness of Contaminants in Food Supplements and their Health Implications, 5th European Lifestyle Medicine Congress
• 2022, Cytotoxic effects of the SOD mimic MnTnHex-2-PyP5+ and its combination with cisplatin in non-small cell lung cancer cells
• 2019-10-10, Migration and invasion of human renal cancer cells are impaired upon treatment with thymoquinone, Toxicology Letters 2019; 314
• 2018-10-08, Choline-based ionic liquids to deliver poorly soluble drugs in topical delivery systems, 27th EuCheMS Conference on Molten Salts and Ionic Liquids
• 2018-10-04, Choline-amino acid ionic liquids as functional excipients for topical delivery of poorly soluble drugs, III CBIOS Seminar
• 2018-10-04, Choline-amino acid ionic liquids as green functional excipients for topical delivery of poorly soluble drugs, III Scientific Conferences CBIOS
• 2018, Cytotoxic effects of the dietary compound thymoquinone in human renal cancer cells, Biomedical and Biopharmaceutical Research 2018; 15(2)
• 2014-09-10, Effect of Cu[15]pyN5 on MDA-MB-231 cell migration and invasion., 50th Congress of the European Societies of Toxicology (EUROTOX)
• 2012-09, Beneficial effects of the redox-active complex Cu[15]pyN5 in doxorubicin-treated breast cancer cells., Society for Free Radical Research International 16th Biennial Meeting

Conference poster

• 2023-11-10, Navigating the Hazards: Understanding Recreational Athletes' Perceptions on Food Supplement Contamination and Adulteration, V Jornadas CBIOS
• 2023-06-19, TransfersomILs: an innovative nanosystem for the cutaneous delivery of hydroxycinnamic acids, NanoMed Europe 2023
• 2023-02-06, Exploring the innovative TransfersomILs for the cutaneous delivery of hydroxycinnamic acids, 4th SPLC-CRS Young Scientists Meeting
• 2022-11-11, Probing the impact of TransferomILs containing rutin in skin physiology ¿ cytotoxicity studies, 2nd International Meeting of the Portuguese Society of Physiology
• 2019-10-03, Effects of the food bioactive erucun on human renal cancer cells, COST Action CA 16112 _ NutRedOx Meeting
• 2019-09-27, Impact of the food bioactive erucin on human renal cancer cells, I Bio.Natural
• 2019-09-08, Migration and Invasion of human renal cancer cells is impaired upon treatment with thymoquinone, EUROTOX 2019 - 55th Congress of the European Societies of Toxicology [P-05-029], 8th - 11th Sep 2019, Helsinki, Finland
• 2018-11-08, Applicability of choline-based ionic liquids as functional excipients in topical formulations containing poorly soluble compounds, 1a Conferência Conjunta sobre Investigação em Produtos Naturais / 4a Reunião de Coordenação da Rede Iberoavícola
• 2018-07, Thymoquinone inhibits the migration and invasion of human renal cancer cells, 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting
• 2018-07, Cytotoxic effects of the food bioactive compound thymoquinone in human renal cancer cells, 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting
• 2018-07, Choline-based ionic liquid as green excipient for topical delivery of poorly soluble drugs , Encontro com a Ciência e Tecnologia em Portugal
• 2014-09, Cytotoxicity, genotoxicity and ROS production by ochratoxin A in Vero cells, Biochemical basis of healthy ageing - SFRR-Europe/IUBMB Advanced School
• 2012-12, Role of the redox-active complex Cu[15]pyN5 in doxorubicin-treated breast cancer cells, 4th Postgraduate iMed.UL Students Meeting

Journal article

• 2023-07-27, The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP5+, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin, Cancers
• 2023-07-19, Functional Foods for Health: The Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables and Culinary Herbs, Foods
• 2023-07, Anthracyclines versus No Anthracyclines in the Neoadjuvant Strategy for HER2+ Breast Cancer: Real-World Evidence, Clinical Drug Investigation
• 2023-02, The Dietary Isothiocyanate Erucin Reduces Kidney Cell Motility by Disturbing Tubulin Polymerization, Molecular Nutrition & Food Research
• 2023, Evaluation of the Lysyl Oxidase-Like 2 (LOXL2) inhibitory activity of pimaranes and their glycosyl derivatives, Journal Biomedical and Biopharmaceutical Research
• 2022-11-07, MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells, Antioxidants
• 2022-08-03, Tumor-infiltrating lymphocytes in early breast cancer: an exploratory analysis focused on HER2+ subtype in Portuguese patients, Current Medical Research and Opinion
• 2022-04, Polyphenols and Their Metabolites in Renal Diseases: An Overview, Foods
• 2021-12-21, TransfersomILs: From Ionic Liquids to a New Class of Nanovesicular Systems, Nanomaterials
• 2021-06, A narrative review of the migration and invasion features of non-small cell lung cancer cells upon xenobiotic exposure: insights from in vitro studies, Translational Lung Cancer Research
• 2021-04-21, Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool, International Journal of Molecular Sciences
• 2021-04, The evaluation of tumor-infiltrating lymphocytes (TILs) in early breast cancer: differences between histologic subtypes in a Portuguese cohort, The Breast
• 2021-04, Systemic treatment of HER2-positive breast cancer patients with brain metastases: current status and exploratory case study in a Portuguese cohort, Biomedical and Biopharmaceutical Research Journal
• 2021-04, Post neoadjuvant HER2 treatment: real world data from a multicentric cohort, The Breast
• 2021, Tratamento sistémico do carcinoma de mama HER2 positivo com metástases cerebrais : estado atual e estudo exploratório de casos numa coorte portuguesa
• 2020-10-05, (Bio)Technological aspects of microalgae pigments for cosmetics, Applied Microbiology and Biotechnology
• 2020-06-24, Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion, Antioxidants
• 2020-04, In vitro anticancer activity of phenolic bioactive compounds studied in a human renal cancer cell model - Supplement III Lusófona’s Nutrition Meeting, Biomedical and Biopharmaceutical Research Journal
• 2020-03, In vitro cytotoxicity assessment of ferulic, caffeic and p-coumaric acids on human renal cancer cells, Biomedical and Biopharmaceutical Research Journal
• 2020-02-04, Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells, Biomolecules
• 2020-02, A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells, Food and Chemical Toxicology
• 2020-01-19, Anti-Migratory and Pro-Apoptotic Properties of Parvifloron D on Triple-Negative Breast Cancer Cells, Biomolecules
• 2020, Avaliação da citotoxicidade in vitro dos ácidos ferulico, cafeico e p-cumárico em células renais tumorais humanas
• 2020, Anticancer activity of rutin and its combination with ionic liquids on renal cells
• 2020, (Bio)Technological aspects of microalgae pigments for cosmetics, Applied Microbiology and Biotechnology
• 2019-10-17, The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells, Antioxidants
• 2019-09-10, Contaminants: a dark side of food supplements?, Free Radical Research
• 2019-06, Cytotoxic effect of antioxidants found in food from plant origin on human osteosarcoma U2OS Cells, Journal Biomedical and Biopharmaceutical Research
• 2019, The manganese(III) porphyrin MnTnHex-2-PyP⁵⁺ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells, Redox Biology
• 2019, Migration and invasion of human renal cancer cells are impaired upon treatment with thymoquinone, Toxicology Letters
• 2019, Cytotoxic effect of antioxidants found in food from plant origin on human osteosarcoma U2OS cells [Efeito citotóxico de antioxidantes de alimentos de origem vegetal em células de osteossarcoma humano U2OS], Biomedical and Biopharmaceutical Research
• 2018-12, Choline-Amino Acid Ionic Liquids as Green Functional Excipients to Enhance Drug Solubility, Pharmaceutics
• 2018-05, Beneficial impact of a manganese(III) porphyrin in cancer cell migration, Free Radical Biology and Medicine
• 2018-05, Anti-tumor properties of the redox-active compound Parvifloron D in breast cancer cells, Free Radical Biology and Medicine
• 2018, Proceedings - CBiOS Scientific Sessions - 2018, Journal Biomedical and Biopharmaceutical Research
• 2018, P-247 - Anti-tumor properties of the redox-active compound Parvifloron D in breast cancer cells, Free Radical Biology and Medicine
• 2018, P-240 - Beneficial impact of a manganese(III) porphyrin in cancer cell migration, Free Radical Biology and Medicine
• 2017-12, Cytotoxicity of N-nitrosoguanidines in a breast cancer cell model, Journal Biomedical and Biopharmaceutical Research
• 2017, Viability and migration of human renal cancer cells upon treatment with a superoxide dismutase mimic, Toxicology Letters
• 2017, The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel, Chemical Biology and Drug Design
• 2017, European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS), Redox Biology
• 2016-12, Xanthine Oxidase Inhibitory Activity of a Plectranthus saccatus aqueous extract, Journal Biomedical and Biopharmaceutical Research
• 2016, Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1, Chemical Biology and Drug Design
• 2016, Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints, Food and Chemical Toxicology
• 2016, Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy, Therapeutic Delivery
• 2016, Effect of MMP inhibitors on the migration of breast cancer cells, Toxicology Letters
• 2015-10, Targeting APE1 redox function with E3330: Effects on the migration of MDA-MB-231 cells, Toxicology Letters
• 2015-10, Ionic liquids as solubility/permeation enhancers for topical formulations: Skin permeation and cytotoxicity characterization, Toxicology Letters
• 2015-10, Hybrid nanoparticles for photodynamic and targeted cancer therapy: Cytotoxicity studies, Toxicology Letters
• 2015-10, Effect of the SOD mimetic MnTnHex-2-PyP on the generation of ROS and cytotoxicity induced by ochratoxin A, Toxicology Letters
• 2015-10, Cytotoxicity screening of Plectranthus spp. extracts and individual components in MDA-MB-231 cells, Toxicology Letters
• 2013-08, Induction of micronuclei and cytotoxic effects of ochratoxin A in Vero cells, Toxicology Letters
• 2013-08, Effect of APE1 inhibitors on the cytotoxicity and genotoxicity of doxorubicin in MDA-MB-231 cells, Toxicology Letters
• 2013, Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxicity in MDA-MB-231 human breast cancer cells, Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Book chapter

• 2021, Fruit and vegetable juices and Breast Cancer, Cancer: Oxidative Stress and Dietary Antioxidants, 2nd, Elsevier - Academic Press
• 2020, Cosmetic Applications, Microalgae - Cultivation, Recovery of Compounds and Applications, 1st, Elsevier - Academic Press
• 2018, Toxicodinâmica, Toxicologia Fundamental, LIDEL, Edições Técnicas, Lda.

Other output

• 2019-10-02, Anticancer properties of thymoquinone in 786-O renal cancer cells, Oral communication in international meeting, NutRedOx COST Action CA 16112 Meeting, [19], 2nd - 4th Oct 2019, Lisbon, Portugal
• 2019-04-01, Modulation of cancer cell migration by redox-active compounds, Invited oral communication at Meeting da COST Action CA15214 (EuroCellNet) - Mechanobiology of Migrating Cells: From Basic Science to the Clinic, [26], 1st - 2nd Apr 2019, Coimbra, Portugal.
• 2019-02-06, Anticancer activity of thymoquinone in human renal cancer cells, Oral communications in National Meeting. SPF2019 - XLIX Reunião anual da Sociedade Portuguesa de Farmacologia/XXXVII Reunião de Farmacologia Clínica/XVIII Reunião de Toxicologia, [CO5.4], 6 -8 de February 2019, Porto, Portugal
• 2017, Redox modulation by sod mimics in renal cancer: from etiology to progression, Cancer is a multistep process and oxidative stress has been pointed out to have critical roles on its initiation, promotion and progression. This thesis addresses the redox modulation afforded by the superoxide dismutase mimic (SODm) MnTnHex-2-PyP (MnP), a prototype of the Manganese(III) porphyrins (MnPs), which are catalytical polyfunctional antioxidants with the ability to modulate different cel