Docente
Granja, T.

Resume

O Tiago Granja graduou-se em Engenharia Biotecnológica na Universidade Lusófona ¿ Lisboa ¿ Portugal e concluiu o mestrado em Biologia Celular e Molecular na Universidade de Coimbra ¿ Coimbra ¿ Portugal de onde se mudou para Bristol ¿ UK para iniciar o seu doutoramento no laboratório MICF ¿ Myocardial Inflammation and Cellular Function no Bristol Royal Infirmary ¿ Bristol ¿ UK. Juntamente com o professor Zackarowski contribuiu para o desenvolvimento de novas funções do recetor de imunidade inata TLR4 e sua sincronização com o eixo hipófise ¿ glândula pituitária ¿ glândulas adrenais e a homeostase cardíaca. Terminou o seu doutoramento em medicina translacional dentro do consorcio da Goethe Universität Frankfurt am Main ¿ Alemanha e Tübingen Universtät Klinikum ¿ Alemanha onde foi responsável pela implementação de novos modelos de microcirurgia animal de inflamação crónica e aguda. Juntamente com o professor Rosenberger em Tübingen concentrou-se na importância da sinapse neuro-imune nos processos inflamatórios em órgãos de choque. Desde então tem-se dedicado ao papel das proteínas neuronais guia na imunidade inata, na função plaquetária, no recrutamento de monócitos, na diferenciação de macrófagos e na sinalização da patofisiologia de ARDS (Acute Respiratory Distress Syndrome) ou IRI (Ischemia/reperfusion Injury). Em 2021 o Tiago Granja integrou o CBIOS (center of Biological Sciences da Universidade Lusófona) onde abraçou a iniciativa de iniciar uma nova carreira na área da imunologia e patofisiologia da microcirculação. Juntamente com o Professor Luís Monteiro Rodrigues explora os limites da Tomografia optoacústica e a sua capacidade em gerar informação 4D de manobras clássicas da fisiologia. Na vanguarda desta tecnologia, no futuro planeia usar a optoacustica como janela de observação da perfusão microvascular, prevenir e diagnosticar alterações cardiovasculares de forma não-invasiva.

Graus

• Postgraduate Certificate
  Anaesthesiologie und Intensivmedizin
• Doktor (PhD)
  FIRST Graduate School
• Postgraduate Certificate
  Molecular Cardioprotection and Inflammation
• Mestrado
  Stress and transcription
• Licenciatura
  Engenharia Biotecnológica
• Curso de Especialização Tecnológica
  Data Science with Python
• Especialização pós-licenciatura
  Formador
• Curso de Especialização Tecnológica
  NoCode Specialist
• Pós-Graduação
  Medical Science Liasion

Publicações

Artigo em revista

• 2024, Targeting Gai2 in neutrophils protects from myocardial ischemia reperfusion injury, Basic Research in Cardiology
• 2024, Semaphorin 7A coordinates neutrophil response during pulmonary inflammation and sepsis, Blood Advances
• 2023, The acute adaptation of skin microcirculatory perfusion in vivo does not involve a local response but rather a centrally mediated adaptive reflex, Frontiers in Physiology
• 2023, Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling, Frontiers in Immunology
• 2023, Comparative view of reactive hyperemia perfusion changes in the upper-limb by laser Doppler flowmetry and optoacoustic tomography and meta-analysis, Journal Biomedical and Biopharmaceutical Research
• 2022-10-18, Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology, Life
• 2022-09-27, Platelets and the Cybernetic Regulation of Ischemic Inflammatory Responses through PNC Formation Regulated by Extracellular Nucleotide Metabolism and Signaling, Cells
• 2022-06, Multispectral Optoacoustic Tomography for Functional Imaging in Vascular Research., Journal of visualized experiments : JoVE
• 2022-02-23, Perfusion, Stance and Plantar Pressure Asymmetries on the Human Foot in the Absence of Disease—A Pilot Study, Symmetry
• 2022-01, Optoaccoustic Tomography – good news for microcirculatory research, Journal Biomedical and Biopharmaceutical Research
• 2022, Left ventricular assist device implantation causes platelet dysfunction and proinflammatory platelet-neutrophil interaction, Platelets
• 2022, Effects of a Multicomponent Exercise Training Program on Balance Following Bariatric Surgery, International Journal of Sports Medicine
• 2020-05, Multi-Modal Characterization of the Coagulopathy Associated With Extracorporeal Membrane Oxygenation, Critical Care Medicine
• 2020-03-11, Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb, Nature Communications
• 2020, The authors reply, Critical Care Medicine
• 2019, Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study, Critical care medicine
• 2018, Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning, Basic research in cardiology
• 2016-09, Adenosine Receptor Adora2b Plays a Mechanistic Role in the Protective Effect of the Volatile Anesthetic Sevoflurane during Liver Ischemia/Reperfusion., Anesthesiology
• 2016-08, Inhibition of Plexin C1 Protects Against Hepatic Ischemia-Reperfusion Injury., Critical care medicine
• 2016-05, The neuroimmune guidance cue netrin-1 controls resolution programs and promotes liver regeneration., Hepatology (Baltimore, Md.)
• 2016-04, Inhibition of Adenosine Kinase Attenuates Acute Lung Injury., Critical care medicine
• 2016, Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury., PloS one
• 2015-10, Using six-colour flow cytometry to analyse the activation and interaction of platelets and leukocytes – A new assay suitable for bench and bedside conditions, Thrombosis Research
• 2015, Erratum: Gai2- and Gai3-deficient mice display opposite severity of myocardial ischemia reperfusion injury (PLoS ONE (2014) 9:5 (e98325) doi:10.1371/journal.pone.0098325), Plos One
• 2014-09, The plexin C1 receptor promotes acute inflammation., European journal of immunology
• 2014-09, Inhibition of neogenin dampens hepatic ischemia-reperfusion injury., Critical care medicine
• 2014-06, Vagus nerve controls resolution and pro-resolving mediators of inflammation., The Journal of experimental medicine
• 2014, Gai2- and Gai3-deficient mice display opposite severity of myocardial ischemia reperfusion injury., PloS one
• 2013, The uncoordinated-5 homolog B (UNC5B) receptor increases myocardial ischemia-reperfusion injury, PLoS One
• 2013, Crucial role of Plexin C1 for pulmonary inflammation and survival during lung injury, Mucosal Immunol
• 2012, The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury, PLoS One
• 2012, The guidance receptor neogenin promotes pulmonary inflammation during lung injury, FASEB J
• 2012, The axonal guidance receptor neogenin promotes acute inflammation, PLoS One
• 2010-10, Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion., Critical care medicine
• 2010, Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury, Crit Care Med
• 2010, Erratum: Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury (Critical Care Medicine (2010) (903)), Critical Care Medicine

Outra produção

• 2021, Control of Neutrophil activation through Semaphorin 7A-Plexin C1 is essential for immune defense during pulmonary sepsis