Class Fundamentals of Bioprocesses

The course aims to familiarize the student with the concept of bioprocesses as well as with the basic acpects of mass and energy balance, allowing him to perform mass balances and enthalpic balances in bioprocesses. In this way the student will have a quantitative perspective of mass and energy flow in a production process based on a biological matrix

Fundamentals of mass balances. law of conservation of mass
Methodologies and criteria for carrying out mass balances. Block diagram
Steady state mass balances: a) mass balances for reactionless processes - separation and mixing; b) mass balances for processes with (bio)reaction. Main reaction, limiting reagent and excess. Percentage of excess, conversion, yield and selectivity. Stoichiometry of cell growth and product formation. Efficiency: c) processes with by-pass, recycling and purge
General energy concepts. Intensive and extensive properties. Introduction to energy balance
Enthalpy: calculation methods. Enthalpy variation in unreacted systems: changes in phase, temperature, heat of solution and mixture. Energy balance methodologies
Heat of reaction and heat of combustion. Energy balance to cell cultures

Teaching: theoretical classes (expository, power point presentations, previously available) for presentation and debate of theoretical concepts and case studies; theoretical-practical classes where different type exercises are proposed and carried out, following sequentially the themes presented in the theoretical sessions. In this context, students work on practical cases to solve real-world problems. In solving and analyzing problems, they also use knowledge acquired in other CUs, promoting collaborative learning. Students are encouraged to study content at home using a variety of devices and platforms, including mobile devices, before class for later class discussion and group work.
Continuous evaluation
Written tests (two tests or a final global te) minimstum average of 10 values, or minimum classification of 10 values, respectively (70% of the final grade) and a written work (30% of the final grade).
Exam
Final written exam

• Prazeres, D.M. (2022). - Exercícios e cálculos introdutórios em engenharia de bioprocessos. Lisboa, IST Prress, ISBN: 978-989-8481-92-4
• Simpson, R., Sastry, S. K. (2013) Chemical and Bioprocess Engineering: Fundamental Concepts for First-Year Students. New York: Springer (ISBN  978-1461491255)