Maria Adília Januário Charmier

Maria Adília Januário Charmier


Adilia Januário Charmier- PhD in Organic Chemistry (1993), Université Blaise Pascal (France). She is currently Full Professor at Universidade Lusófona (ULHT, Lisbon, Portugal) and director of the Biotechnology programs (Engineering and Licenciate degrees) as well as director of the Postgraduate Program in Circular Economy in collaboration with the IMAT group of the University of Trier, IfaS, Germany. She dedicated her academic career teaching courses in the field of General Chemistry, Organic Chemistry and Chemistry of natural products, supervising several national and international Masters and PhD students as well as international postdoctoral researchers In terms of research, she is the coordinator of the research centre DREAMS at the Faculty of Engineering of ULHT and researcher at the centre of Structural Chemistry (CQE) at IST-UNL (Portugal). Its main scientific research includes 1)- the extraction of medicinal plants and wastes using green microwave technologies and bioprocesses for the production of new biologically active products and their applications in the fields of health, pharmaceutical, nutraceuticals and biomaterials and 2)- the synthesis of new biological Metal-coordinated compounds using natural compounds as ligands. In addition, since 2017 she has worked as Scientific Sénior Advisor in various international companies (Cerebio,Coutras, France and EXMceuticals inc., Vancouver, Canada) supervising funded research projects in collaboration with Universidade Lusófona. She has been the co- founder of the portuguese subsidiary EXMceuticals Portugal Lda where she was CEO until December 2019. Currently she is the Vice President of Research and Development of the Company EXMCeuticals. Her scientific research activity resulted in 70 national and international scientific publications distributed by peer-reviewed international journals, conferences and 3 patents and also has been marked by the participation and organization of seminars and conferences in collaboration with several national and international institutions namely, the Instituto Superior Técnico (Portugal), the University of Edinburgh (Scotland), the University of Trier, IfaS, (Germany), the University positivo (Brasil), the University of Al Akhawayn, Ifrane (Morroco).


  • Doctorat
    Doutoramento Química Orgânica Fina
  • DEA
    Diplôme d'études approfondies
  • Maîtrise


Artigo em revista

  • 2023-03-06, Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regeneration: An Experimental Approach from Fundamental to Translational Research, Gels
  • 2022-06, International circular economy strategies and their impacts on agricultural water use, Cleaner Engineering and Technology
  • 2021-03, Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward, Cancers
  • 2020-04-27, How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using Ex-Vivo, In Silico, and In Vivo Models, Biomolecules
  • 2019-12, Integrated Green Chemical Approach to the Medicinal Plant Carpobrotus edulis Processing, Scientific Reports
  • 2019-02, Enhanced pseudo-halide promoted corrosion inhibition by biologically active zinc(II) Schiff base complexes, Chemical Engineering Journal
  • 2019-01, A new Cu(II)-O-Carvacrotinate complex: Synthesis, characterization and biological activity, Journal of Inorganic Biochemistry
  • 2016, N-H...O and N-H...Cl supported 1D chains of heterobimetallic Cu(II)/Ni(II)-Sn(IV) cocrystals, Dalton Transactions
  • 2016, Copper complexes with a flexible piperazinyl arm: nuclearity driven catecholase activity and interactions with biomolecules, Journal of Coordination Chemistry
  • 2015, Synthesis, molecular structure and stability of fused bicyclic ¿4-1,2,4-oxadiazoline Pt(II) complexes, Polyhedron
  • 2014, Characterization of the antiproliferative potential and biological targets of a trans ketoimine platinum complex, Inorganica Chimica Acta
  • 2010, ChemInform Abstract: Chemoselectivity in the Manipulation of Polyhydroxylated Compounds Derived from the Diastereoselective Dihydroxylation of Optically Active Allylic Enoate Alcohols., ChemInform
  • 2010, ChemInform Abstract: An Expedient Stereoselective Synthesis of Polysubstituted Piperidin-2-ones., ChemInform
  • 2010, ChemInform Abstract: 1,3-Dipolar Cycloaddition Reactions of Nitrones with Vinylacetic Olefins in the Racemic Series and Synthesis of d-Lactams via Isoxazolidines., ChemInform
  • 2010, ChemInform Abstract: 1,3-Dipolar Cycloaddition Reactions of Nitrones with Unsaturated Methylsulfones and Substituted Crotonic Esters., ChemInform
  • 2009-01-08, ChemInform Abstract: Efficient Regioselective Synthesis of 4- and 5-Substituted Isoxazoles under Thermal and Microwave Conditions., Journal of Heterocyclic Chemistry
  • 2009, Synthesis of mono- and bis-tetrazolato complexes of Ni(II), Pt(II) and Cu(II) via 1,3-dipolar cycloadditions of 2-cyanopyridines with metal ligated azides in N,N,O-aminoiminophenolato complexes, Dalton Transactions
  • 2009, Synthesis of lactones by desymmetrization. A synthesis of (-)-muricatacin, Tetrahedron
  • 2009, PdII-promoted [2 + 3] cycloaddition of pyrroline N-oxide to organonitriles. Application of (¿4-1,2,4-oxadiazoline)-PdII complexes in the Suzuki–Miyaura reaction, Dalton Transactions
  • 2008, PtII-promoted [2 + 3] cycloaddition of azide to cyanopyridines: Convenient tool toward heterometallic structures, Inorganic Chemistry
  • 2008, New water-soluble azido- and derived tetrazolato-platinum(ii) complexes with PTA. Easy metal-mediated synthesis and isolation of 5-substituted tetrazoles, Dalton Transactions
  • 2008, Metal-Free and Pd II -Promoted [2+3] Cycloadditions of a Cyclic Nitrone to Phthalonitriles: Syntheses of Oxadiazolines as well as Phthalamide-Pd II and Dihydropyrrolyl-iminoisoindolinone-Pd II Complexes with High Catalytic Activity in Suzuki-Miyaura Cross-Coupling Reactions, Chemistry - A European Journal
  • 2008, Efficient regioselective synthesis of 4- and 5-substituted isoxazoles under thermal and microwave conditions, Journal of Heterocyclic Chemistry
  • 2008, Activation of C–CN bond of propionitrile: An alternative route to the syntheses of 5-substituted-1H-tetrazoles and dicyano-platinum(II) species, Polyhedron
  • 2007, Trans-Bis(triphenylphosphine)-bis{5-(4-fluorophenyl) -2H-tetrazolatoN2}platinum(II), Acta Crystallographica Section E,m2656: Structure Reports Online
  • 2007, Stereospecific Synthesis of Polysubstituted E -Olefins by Reaction of Acyclic Nitrones with Free and Platinum(II) Coordinated Organonitriles, The Journal of Organic Chemistry
  • 2007, Optically Active Mixed Unsymmetric Imine Platinum(II) Complexes - Utilization of the Liberated Imines for Further Syntheses of Mixed Imine-Diazadiene Complexes and of ( E )-Cyanoalkenes, European Journal of Inorganic Chemistry
  • 2007, Mixed unsymmetric oxadiazoline and/or imine platinum(ii) complexes, Dalton Transactions
  • 2007, Microwave synthesis of mono- and bis-tetrazolato complexes via 1,3-dipolar cycloaddition of organonitriles with platinum(ii)-bound azides, Dalton Transactions
  • 2006, Direct synthesis of (imine)platinum(ii) complexes by iminoacylation of ketoximes with activated organonitrile ligands, Dalton Transactions
  • 2005, Stereoselective synthesis of optically active mono and diaminoalcohols, Tetrahedron
  • 2004, Unprecedented single-pot synthesis of nitrile-derived ketoimino platinum(II) complexes by ring opening of ¿4-1,2,4- oxadiazolines, Dalton Transactions
  • 2003, Microwave-assisted [2 + 3] cycloaddition of nitrones to platinum-(II) and -(IV) bound organonitriles, Dalton Transactions
  • 2002, An expedient stereoselective synthesis of polysubstituted piperidin-2-ones, Tetrahedron
  • 1999, 1,3-Dipolar Cycloaddition Reactions of Nitrones with Unsaturated Methylsulfones and Substituted Crotonic Esters, Journal of Chemical Research
  • 1996, Chemoselectivity in the manipulation of polyhydroxylated compounds derived from the diastereoselective dihydroxylation of optically active allylic enoate alcohols, Tetrahedron
  • 1995, 1,3-Dipolar Cycloaddition Reactions of Nitrile Oxides with 1,3-Dioxolanes of .alpha.,.beta.-Unsaturated Aldehydes, The Journal of Organic Chemistry
  • 1994-04-18, 1,3-Dipolar Cycloaddition Reactions of Nitrile Oxides with Chiral Vinylacetic Olefins in Racemic Series., J. Chem. Research (S)
  • 1994, 1,3-Dipolar cycloaddition reactions of nitrones with vinylacetic olefins in the racemic series and synthesis of d-lactams via isoxazolidines, Journal of Heterocyclic Chemistry

Tese / Dissertação

  • 1993-02-21, Doutoramento, Cycloaditions dipolaires-1,3 de nitrones et de nitriloxydes sur des olefines captodatives, crotoniques et vinylacétiques. Obtention d'aminoalcools, cyclisation en lactames

Artigo em jornal

  • 2022-02-15, Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity Tackling a Therapeutic Strategy, Frontiers in Immunology

Artigo em conferência

  • 2019, A Survey on Sustainable Product Development, 25th International Conference on Production Research Manufacturing Innovation: Cyber Physical Manufacturing, Chicago

Poster em conferência

  • 2019-05-06, Risk Communication of Climate Change in Portugal,” Society for Risk Analysis, Society for Risk Analysis, 5th World Congress on Risk, “New challenges, new threats: Resilience and adaptation in a risky world”, Cape Town, South Africa
  • 2018-09-04, A novel Cu(II)-O-carvacrotinate complex: studies of antimicrobial and antiproliferative activities, 7th EuChemS Conference on Nitrogen-Ligands
  • 2017-09-03, Circular Economy and Sustainability: from grape winery wastes to value-added goods, 3rd EuCheMS Congress on Green and Sustainable Chemistry, UK (EuGSC)
  • 2017-07-16, HPLC-DAD-HRMS characterization of the bioactive phenolic compounds in aqueous extracts of Origanum vulgares L, Encontro Nacional da SPQ (XXV-EN)” , Faculdade de Farmácia da Universidade de Lisboa
  • 2017-07-16, HPLC-DAD-HRMS characterization of Carpobrotus edulis L. extracts processed by an integrated Green Chemical approach, Encontro Nacional da SPQ (XXV-EN)” , Faculdade de Farmácia da Universidade de Lisboa
  • 2017-07-09, Synthesis of a New Class of Promising Copper Complexes with Carvacrol and O-Carvacrotinic Acid Ligands, EUCHEMS International Organometallic Conference XXII, Amsterdam
  • 2017-05-26, Economia Circular : Produtos naturais vs. Infeções hospitalares-Resíduos hospitalares , Comunicação-VI Jornadas da Associação Portuguesa de Hotelaria Hospitalar (APHH), Hospital Pediátrico do CHUC, Coimbra
  • 2017-04-03, Microwave technology and enzymatic modifications of plant extracts to obtain compounds with antibacterial activity, Microbiology Society Annual Conference, Edinburgh, Scotland.
  • 2017-01-26, Sustentabilidade Ambiental e Empresarial na Gestão de Resíduos, Comunicação-Meeting on Energy Efficiency and Environmental Sustainability and Business, Maia
  • 2016-09-11, Towards Green Downstream Processing Microwave Technology for Extraction of Active Biomolecules, European Symposium on Biochemical Engineering Sciences (ESBES), 1Dublin, Ireland
  • 2016-05-24, Transdisciplinaridade na Economia Circular, Comunicação oral-International Conference in Circular Economy CIEC, Montalegre
  • 2015-10-04, Green approach to phytochemicals extraction, 2nd EuChemMS Congress on Green and Sustainable Chemistry, Lisbon
  • 2015-10-04, Green Microwave technology and enzymatic modifications applied to natural products and plant extracts: new solutions for old problems, 2nd EuChemMS Congress on Green and Sustainable Chemistry, Lisbon
  • 2015-09-02, Exploration of Microwave technology in plants extraction and synthesis of novel biorganometallic natural products. Study of their biological properties, International Symposium on Synthesis and Catalysis, ISySyCat, Evora
  • 2015-03-25, Extraction of Bioactive natural products via microwave technology and their biosynthetic modification, Congress Directing Biosynthesis IV, Norwich, UK
  • 2014-07-30, Synthesis, Characterization and Antibacterial, Antioxidant and Antitumoral Evaluations of Novel Zn(II) Schiff Bases and Flavonoids Derivatives Complexes , AGICHEM, 9th Anglo-German Conference on Inorganic Chemistry, Edinburgh
  • 2013-01-07, Antiproliferatrive potential and biological targets of new platinum complex and their applications, 20th EuCheMS Conference on Organometallic Chemistry), St Andrews, Scotland
  • 2013, Determination of Alcohol, pH and Density in Portuguese wines using a Method of Near-infrared (NIR) , IN VINO ANALYTICA SCIENTIA, Reims, France. In vino analytica Scientia
  • 2012-09-16, Cerveja sem diacetilo: processamento enzimático e NIR (SpectraAlizer), 11º congresso de Química dos Alimentos, Bragança, Portugal
  • 2012-09-02, Characterization of the antiproliferatrive potential and biological targets of new platinum complex, XXV ICOMC, XXV XXV International Conference on Organometallic Chemistry, Lisbon
  • 2010-12-11, Interaction of cis-[Pt(N3)2(PPh3)2] with Different Alkenenitriles : Cycloaddition and Unusual Activation of Carbon-Carbon Bonds, FRONTIERS IN INORGANIC CHEMISTRY - " held in Indian Association for the Cultivation of Science, Kolkata, India
  • 2008, Platinum(II) Mediated [2+3] Cycloaddition of Azide and Nitrile: a Conveniente Tool towards Heterometallic Supramolecular Chemistry, 1st International Conference on Metal-Organic Frameworks and Open Framework Compounds (MOF08), Angsburg, Germany
  • 2008, Mixed Unsymmetrical Oxadiazoline and/or Imino Platinum(II) Complexes, IXth Netherlands’ Catalysis and Chemistry Conference, Noordwijkerhout, The Netherlands
  • 2007-03, Stereospecific synthesis of Polysubstituted E-Olefins by reaction of Acyclic Nitrones with Free and Platinum(II) Coordinated Organonitriles, Catalysis and Chemistry Conference, Amsterdam
  • 2006-03, Direct synthesis of (imine)Pt(II) complexes by iminoacylation of Ketoximes with activated platinum(II)-coordinated organonitriles, Catalysis and Chemistry Conference, Amsterdam
  • 2004-09-08, Microwave-Assisted [2+3] Cycloaddition of Nitrones to Platinum Organonitriles : A Promising Synthesis of New Biological Active Oxadiazolines and Ketoimines, III Euchem Conference on NITROGEN LIGANDS IN ORGANOMETALLIC CHEMISTRY AND HOMOGENEOUS CATALYSIS“, Camerino, Italy
  • 1997-09-16, 1,3-Dipolar Cycloaddition Reactions of Nitrones with Optically Active Allylic Enoate alcohols and Synthesis of Lactams via Aminoalcohols , 2º Congresso de Química Orgânica em Oeiras, Portugal
  • 1995-07-13, Stereoselective Synthesis of Polyols via Catalytic Mono-Dihydroxylation of di- and dienoate Compounds, 1º Congresso de Química Orgânica em Braga, Portugal
  • 1995-07-13, Reacções de Cicloadição Dipolares-1,3 de Nitronas com Poliois Mono e Bis Alílicos e sua Aplicação na Síntese de Compostos com Actividade Biológica, 1º Congresso de Química Orgânica em Braga , Portugal


  • System and Method of synthesis of polysubstituted E-cyanolefins based on reactions of nitriles with nitrones, PT 103888 , Instituto superior técnico
  • Novos complexos de paladio com ligandos bibíclos de tipo hidropirrolooxadiazole, e sua aplicação como catalisadores em reacções de acoplamento de Suzuki-Miyaura, assistidas por microondas, PT 104199 , Instituto Superior Técnico
  • New palladium complexes with bis(pyrrodinylledene) phthalamides and di hydropyrrolyliminoisoindolinones, and their application as catalysts in Suzuki-Miyaura coupling reactions, PT 104187 , Instituto superior técnico


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