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Presentation
Presentation
The rapid growth of the internet is providing an expansion territory to informations that also turns the diffusion of processing tools easier. Bioinformatics databases and available software for their treatment will be presented. The theoretical concepts (biological and mathematical) at the origin of these treatments will also be mentionned.
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Bachelor | Semestral | 5
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Year | Nature | Language
Year | Nature | Language
2 | Mandatory | Português
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Code
Code
ULHT2710-17406
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
1. Introduction to Bioinformatics. Definition. Evolution and phylogenetic tree of the living world. Macromolecules and informatics. Main Bioinformatics organizations. 2. Databases. Technical considerations. Main databases. 3. Analysis and comparison of sequences. Nucleotide substitution models. Sequence similarity. Sequence comparison methods and evolutionary distance. Sequence alignment. Programs and basic notions. 4. Phylogenetic analysis. Phylogenetic tree models. Tree construction methods. Statistical tests (Bootstrap) and programs. 5. Structural analysis of macromolecules. Protein evolution. Structure prediction. Protein classification. Biomolecule structure determination. Resources and programs. 6. Genomics and proteomics. Genomes (sequencing, annotation, comparison, farmacogenetics). Proteomes (bidimensional electrophoresis, mass spectrometry). Transcriptomes (microarrays).
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Objectives
Objectives
Competences that should be developed: Manipulation of the most important biological data banks and use of various tools provided by bioinformatics to treat these biological data.
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Teaching methodologies
Teaching methodologies
The essentially practical nature of this CU is aimed at developping in the student a know how that will be indispensable in his future carreer. Only the repeted use of the main techniques offered in the course will allow the student to reach the mastery of these techniques.
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References
References
- Graur D. & Li W.-H. (2000). Fundamentals of molecular evolution. Sinauer, Sunderland. - Voet D. & Voet. J.G. (2010). Biochemistry, 4th Ed. John Wiley & Sons, New York.
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Assessment
Assessment
Descrição
Data limite
Ponderação
Frequências (2 provas mais uma 3º prova facultativa de recuperação)
dd-mm-yyyy
65%
Assiduidade
dd-mm-yyyy
10%
Trabalho de grupo
25%
Ensino presencial: Aulas teóricas magistrais com frequência voluntária seguindo o
programa e de acordo com os objectivos da UC. Aulas teórico-práticas tutoradas por um docente, de
frequência obrigatória destinadas a aplicar a dados reais as técnicas descritas.
Requisitos para aproveitamento final:
1) Avaliação contínua por 2 provas teórico-práticas (32,5% + 32,5%) + assiduidade 10% + projeto
desenvolvido nas aulas práticas 25%; classificação total igual ou superior a 10 valores), com todos os
documentos autorizados e com apoio informático.
Ou 2) Exame teórico-prático no final do semestre (75%) + projeto desenvolvido nas aulas práticas 25%
(classificação total igual ou superior a 10 valores), com todos os documentos autorizados e com apoio
informático. Isenção de repetir uma das componentes em caso de nota igual ou superior a 9,5 valores
obtida para esta componente em avaliação contínua ou exame final anterior.Presential teaching: Theoretical lectures of facultative attendance that follow the syllabus and
respect the objectives of the CU. Theoretico-practical classes are mandatory classes under the guidance
of a teacher and intended to practice techniques described in lectures with real data.
Requirements to pass the discipline:
1) Continuous evaluation by 2 midterm exams (32,5% + 32,5%) + class attendance 10% + project
elaborated during the classes 25%; final classification equal or superior to 10), with all documents
allowed and computer provided.
Or
2) Theoretico-practical exam by the end of the semester (75%) + project elaborated during the classes
25% (classification equal or superior to 10), with all documents allowed and computer provided. Students
with a minimum classification of 9,5 for a component at a previous evaluation (continuous evaluation or
previous examination) are exempted from repeating it.
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Mobility
Mobility
No
