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Presentation
Presentation
Genetics studies genes and how characteristics are transmitted from generation to generation, as well as gene expression and its modulation by intrinsic and extrinsic factors. From this perspective, this curricular unit is fundamental within the context of this degree program, as it provides a solid foundation for understanding cellular chemical processes. The theoretical component offers essential knowledge, which will later be applied in the practical component in the laboratory, through the use of various DNA analysis methodologies
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Bachelor | Semestral | 5
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Year | Nature | Language
Year | Nature | Language
2 | Mandatory | Português
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Code
Code
ULHT2710-954
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
I. Structure and Organization of Genetic Material DNA and chromatin DNA replication and chromosome structure as the physical vehicle of genetic information; structure and function of replication origins, centromeres, and telomeres II. Gene Expression Processes: Transcription and Translation Transcriptional regulation mediated by regulatory proteins and chromatin conformation III. Prokaryotic and Eukaryotic Genomes IV. Genetic Information Regulation Processes Mutation and DNA repair mechanisms Transposons and repetitive sequences V. Classical Genetic Analysis Independently segregating genes (multiple alleles, lethal alleles, gene interactions, and sex-linked traits) VI. Basic Molecular Genetics Techniques – Practical Component: DNA extraction from eukaryotic cells and plasmids Spectrophotometry and electrophoresis in nucleic acid analysis Study of polymorphisms Restriction map analysis
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Objectives
Objectives
The main objective of this curricular unit is to provide students with foundational knowledge in the scientific field of Genetics, fostering an understanding of the molecular mechanisms that control heredity and gene expression, namely: The molecular foundations of genetics, including DNA replication, RNA transcription, protein translation, and the mechanisms associated with mutation processes; The fundamental processes of gene expression, with emphasis on transcription, translation, and differential regulation strategies of gene expression in various cellular and physiological contexts; The principles and mechanisms of inheritance, based on classical genetic laws and recent advances in molecular genetics. Beyond the theoretical concepts, the CU aims to equip students with a conceptual framework applicable to various scientific and professional contexts, particularly in the fields of biomedical research, clinical diagnostics, genetic therapies, and biotechnology.
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Teaching methodologies and assessment
Teaching methodologies and assessment
With the aim of fostering critical thinking and enhancing students? ability to apply acquired knowledge to real-world contexts , students will develop thematic seminars, guided by a problem-based learning (PBL) approach. The seminar topics will be selected based on current and relevant applications of genetics, such as: Diagnosis and prognosis of genetic diseases using genetic markers; Analysis of gene regulation mechanisms , including epigenetics and post-transcriptional regulation; Emerging technologies , such as CRISPR-Cas9 and gene editing; Bioethics and the social implications of genetic manipulation . Each seminar presentation will be followed by a structured discussion, encouraging participation from fellow students and promoting collaborative learning. This methodology not only strengthens knowledge retention but also develops key transversal skills such as teamwork, evidence-based argumentation, and scientific autonomy.
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References
References
Hartl, Daniel L. Essential genetics and genomics 7th ed. Jones & Bartlett Learning, USA, 2020. ISBN: 9781284152456 Brooker, Robert J. Genetics: Analysis and Principles. 6th ed. McGraw-Hill Education, USA, 2017. ISBN-13: 978125961602 Griffiths, Anthony J.F.; Wessler, Susan R.; Carroll, Sean B.; Doebley, John. Introduction to Genetic Analysis 11th ed. W.H. Freeman, UK, 2015. ISBN-13: 9781464109485
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Office Hours
Office Hours
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Mobility
Mobility
No
