Class Human Anatomy

Fundamentals of Anatomy, Physiology and Genetics” (FAFG) integrates the scientific core-base of the Integrated Master in Computational Biomedicine and Artificial intelligence, positioning itself as the first bridge between classical biomedical sciences and digital health technologies. This Curricular unit (UC) operates in the domains of human morphology, physiological homeostasis and genetic inheritance, articulating them with the exploration of clinical data, predictive algorithms and Medical Decision Support Systems. Its field of action extends from the identification of anatomical patterns in imaging, through the modeling of physiological networks, to the interpretation of genetic variants in large omic cohorts, always under the ethical scrutiny that governs digital health.

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Knowledge: Organization of physiological systems Mastering anatomy, physiology, and genetics, understanding body structure and function, basic physiology, and genetics. Understanding: homeostasis, biological processes and their monitoring  Interpreting fundamental biological and genetic processes, relating them to health and disease, and advancements in digital health. Application: thinking holistically Applying anatomy, physiology, and genetics knowledge to solve practical problems and evaluate new technologies in digital health. Analysis: impact of disease on anatomy, physiology and Genetics Critically evaluate the relationship between body structure and function and genetic variations in health and disease, considering ethical challenges. Synthesis: digital reference networks in human medicine studies. Evaluation: extraction of relevant information from digitalized literature  

Setup tools for publishing a paper on Neuronal guidance Proteins and Inflammation:  **Boot-camp** – 90 min crash course on semaphorin biology & inflammation timelines  **Taxonomy & Anatomy** – map every human semaphorin to tissue expression (GTEx, HPA)  **Genetics** – catalogue coding & regulatory variants linked to inflammatory disease (ClinVar, GWAS Catalog)   **Physiology & Immunology** – link each variant to altered pathways (GO, Reactome)  **Phenotypes** – generate a “Semaphorin-Phenome Atlas” (HPO, OMIM) **Omics Integration** – overlay bulk & single-cell data (GEO, ImmGen) on inflammation models  **Clinical Trials** – mine ClinicalTrials.gov & EU-CTR for semaphorin-targeted interventions **Therapeutic Concepts** – brainstorm small-molecule, biologic, mRNA or gene-editing approaches **Ethics & Regulation** – debate on germline editing, off-target effects **Synthesis** – merge all layers into an open-access e-Book chapter & 5-min elevator video

Martini, F. H., Nath, J. L., & Bartholomew, E. F. (2020). Fundamentals of Anatomy & Physiology (12th ed.). Pearson. Saladin, K. S. (2021). Anatomy & Physiology: The Unity of Form and Function (9th ed.). McGraw-Hill Education. Marieb, E. N., & Hoehn, K. (2020). Human Anatomy & Physiology (12th ed.). Pearson. Gilbert, S. F. (2019). Developmental Biology (12th ed.). Sinauer Associates.