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Presentation
Presentation
Organic Medicinal Chemistry studies the design and development of drugs and the molecular mechanisms of drug interaction with molecular targets. This uc combines the knowledge of chemistry and pharmacology to identify, analyse, develop and synthesize drugs that have a therapeutic use and to assess the properties of existing drugs.
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Bachelor; Master Degree | Semestral | 6
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Year | Nature | Language
Year | Nature | Language
2 | Mandatory | Português
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Code
Code
ULHT477-17208
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
1. Introduction to organic medicinal chemistry: drugs, drug targets and intermolecular interactions. 2. Drug targets: structure and function. Pharmacodynamics and pharmacokinetics. 3. Discovery, design, and development of drugs: prototypes and analogs, isolation, purification, and determination of structure, sources of prototypes, and drugs from natural products, and medicinal plants. Optimization of molecular target interactions. Molecular target access optimization. 4. Tools for commercialization: clinical and pre-clinical trials, patents, regulatory affairs, and chemical process development 5. Tools for medicinal chemistry: Combinatorial and Computational Chemistry, Quantitative Structure-Activity Relations (QSAR). 6. Topics in Medicinal Chemistry: antimicrobial, antiviral, anticancer agents, drugs that affect neurotransmission (cholinergic, adrenergic, and dopaminergic). Opioid and anti-ulcer analgesics.
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Objectives
Objectives
This curricular unit aims to study the structure and function of the most important molecular targets of drugs. Also important are pharmacodynamics and pharmacokinetics, as well as the principles and strategies that involve the discovery and design of new drugs for drug development. The study of drug design involving QSAR relationships (quantitative structure-activity relationships), combinatorial synthesis and drug design with the help of computers, and the selection of specific topics involving medicinal chemistry such as the study of antimicrobial agents, antitumor, cholinergic, and acetylcholinesterase, opioid analgesics and anti-ulcer agents.
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Teaching methodologies
Teaching methodologies
In this course, innovative methodologies are used to optimize the teaching and learning process. Theoretical classes provide the conceptual foundation, while laboratory sessions allow for practical application of the concepts. The educational materials are available on the Moodle platform, with interactive resources. The course includes a fieldwork component, in the form of a visit to a pharmaceutical industry, offering a relevant practical experience. Assessment involves written tests, presentation and discussion of a written assignment, and analysis of scientific articles. Laboratory notebooks are evaluated, including a project using virtual reality (VR4NewDrugs) to simulate the development of new drugs. These methodologies ensure comprehensive and practical learning.
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References
References
1. Patrick, G. L. (2005). An Introduction to Medicinal Chemistry. Oxford: University Press. 2. Thomas, G. (2008). Medicinal Chemistry: An Introduction. New Jersey: John Wiley & sons. 3. Vollhardt, K. P. C., Schore, N. E. (2014). Organic Chemistry: structure and function. New York: Freeman and Company.
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Assessment
Assessment
A unidade curricular compreende aulas teóricas e laboratoriais. Os conteúdos programáticos são abordados nas aulas teóricas, valorizando os conceitos básicos da química farmacêutica orgânica. O material didático de apoio será disponibilizado na plataforma on-line Moodle.
Nesta UC inclui-se ainda um trabalho de campo que está integrado na semana de contacto com a profissão na forma de uma visita de estudo.
A avaliação contínua engloba: Participação e desempenho, 10% (A); um teste escrito (teste das aulas teórica e teste laboratorial), 30% (B); a apresentação e discussão de um trabalho escrito, 30 % (C); a apresentação e discussão de artigos científicos, 10% (D); a apresentação e discussão de cadernos de laboratório incluído o trabalho com uso de realidade virtual VR4NewDrugs, 20% (E) (final = A (10%) + B (30%) + C (30%) + D (10%) + E (20%)).
Para obter aproveitamento, é obrigatória uma nota média mínima de 7,0 valores no teste escrito que inclui teste laboratorial.
O aluno trabalhador-estudante que optar pela avaliação contínua deverá cumprir com os requisitos acima definidos.
A avaliação por exame final aplica-se aos alunos que por ele optem abrangendo a totalidade dos conteúdos programáticos (exame escrito e exame laboratorial).
A melhoria de nota é realizada sob a forma de prova de avaliação oral, englobando a totalidade dos conteúdos programáticos.
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Mobility
Mobility
Yes
