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Presentation
Presentation
The curricular unit Analytical Methods II deepens the study of key instrumental techniques in Pharmaceutical Sciences, with applications in quality control, structural characterization, and drug modulation. It covers chromatographic methods (HPLC, GC, SFC, hyphenated techniques) and electroanalytical techniques (conductimetry, potentiometry, electrogravimetry, coulometry), focusing on their analytical capabilities. The unit aims to equip students with theoretical and practical knowledge to autonomously perform experimental procedures, critically analyze results, and optimize analytical methodologies applied to complex pharmaceutical systems.
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Bachelor; Master Degree | Semestral | 6
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Year | Nature | Language
Year | Nature | Language
2 | Mandatory | Português
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Code
Code
ULHT477-3582
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
1. Chromatographic methods: a) Introduction and optimization of chromatographic separations. Fundamentals and applications: partition chromatography, planar chromatography, ion exchange chromatography and gel chromatography. b) Instrumentation and applications: Liquid Chromatography High Resolution, Gas Chromatography and Supercritical Fluid Chromatography. 2. Technical hyphenated: Concepts and applications. 3. Electroanalytical Methods: a) Conductometry: principles and instrumentation. b) Conductometric analysis methods: direct conductometry and conductometric titrations. c) Electrochemistry and introduction to electroanalytical methods. d) Potentiometry: introduction and instrumentation. Direct potentiometry and potentiometric titrations. e) Electroanalytical techniques: introduction to electrolysis. Fundamentals and applications: electrogravimetric analysis, coulometry, amperometry and voltammetry.
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Objectives
Objectives
The course of Analytical Methods II aims to follow the course of Analytical Methods I and complement the knowledge already gained in this area with other equally important methods within the Pharmaceutical Sciences, focusing on their application to quality control, structural characterization, and drug modulation. Thus, analytical methods II will be addressed, involving the methods of chromatographic separation, with particular relevance for liquid-liquid chromatography (HPLC), gas-liquid chromatography, and, lastly, chromatography with supercritical fluids and hyphenated techniques. Finally, we will study the electroanalytical methods: conductometric methods, potentiometry, electrogravimetry, and coulometry.
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Teaching methodologies
Teaching methodologies
Throughout the teaching of the UC, practical and demonstrative examples of the matter are used.
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References
References
Harris, D.C. (2010). Quantitative Chemical Analysis. New York: W. H. Freeman & Co. ISBN-13: 978-1-4292-1815-3. Skoog, D., Holler, F. J., Crouch S. R. (2007). Principles of instrumental analysis. Belmont: Thomson Brooks/Cole. Skoog, D., Holler, F. J., Crouch S. R. (2013). Fundamentals of Analytical Chemistry, USA: Cengage Learning US. Christian, G.D. (2003). Analytical Chemistry. New York: John Wiley & Sons. Skoog, D., Holler, F. J., Crouch S. R. (2000). Analytical Chemistry: an Introduction. USA: Cengage Learning US.
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Assessment
Assessment
Descrição dos instrumentos de avaliação individual:
Descrição
Ponderação
(A) Um teste escrito e apresentação e discussão de um trabalho sobre eletroquimica
A nota teste deve ser igual ou superior a 8 valores
60%
(B) Apresentação e discussão de cadernos de laboratório
20%
(C) Apresentação de artigo científico
10%
(D) Desempenho e participação nas aulas
5%
(E) Quizzes interativos
5%
A avaliação contínua engloba:
(A) Um teste escrito (engloba teste teórico e teste laboratorial) de 30%, e a apresentação e discussão de um trabalho sobre eletroquímica 30%, o que perfaz 60%; (A nota do teste escrito (engloba teste teórico e teste laboratorial) deve ser igual ou superior a 8 valores.)
(B) Apresentação e discussão de cadernos de laboratório (individual) - 20%
(C) Apresentação de artigo científico – 10%
(D) Desempenho e participação nas aulas - 5%
(E) Quizzes interativos - 5%
Somatório Final = A (60%) + B (20%) + C (10%) + D (5%)+ E (5%)
O aluno trabalhador-estudante que optar pela avaliação contínua deverá cumprir com os requisitos acima definidos.
A avaliação por exame final abrange a totalidade dos conteúdos programáticos (nota mínima de 10 valores).
A melhoria de nota é realizada sob a forma de exame escrito englobando a totalidade dos conteúdos programáticos.
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Mobility
Mobility
No
