-
Presentation
Presentation
This UC has as its main objective to give students a global view on the viruses that cause human pathologies, the structure of the viral particle, the organization, the type of genome, the clinical picture and the techniques / approaches used in the diagnosis, treatment and prevention of these infections.
-
Class from course
Class from course
-
Degree | Semesters | ECTS
Degree | Semesters | ECTS
Bachelor; Master Degree | Semestral | 4
-
Year | Nature | Language
Year | Nature | Language
3 | Mandatory | Português
-
Code
Code
ULHT477-3900
-
Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
-
Professional Internship
Professional Internship
Não
-
Syllabus
Syllabus
1 - Introduction Historical landmarks Virus vs bacteria vs prion Structure and virion elements Environmental survival Taxonomy 2 - Genetics Genome organization Mutation and recombination 3 - Cell-virus interaction Cell and organism virus entry Viral pathogenesis mechanisms Viral gene expression and replication Viral particle assembly and release 4 - Host resistance to viral infection Viral tropism Innate immunity Adaptive immunity Pathological effects and viral infection patters Latent infections Viral oncogenesis 5 - Viral replication inhibition Viral inhibitors, targets and mechanisms 6 - Vaccination Vaccine groups National vaccination program 7 - Viral infections that induce human pathologies Structure, genome, clinical, symptomatology, transmission, pathogenesis, diagnosis techniques and prevention. Epidemiology
-
Objectives
Objectives
After attending this CU, the student should know the main groups of virus that cause human pathologies, their virion structures, genome type, clinical condition and the technique used in diagnostics, treatment and prevention of such infections. The student should understand the mechanisms involved in the host anti-viral immune response. Special attention is given to antiviral compounds, vaccines, their mode of action and viral resistance development. Students gain a deep understanding of the viral diagnosis techniques by performing such assays in practical classes. This approach allows students to consolidate the subjects introduced in the lectures. Students are given a great amount of autonomy in the laboratory as a way to stimulate the student¿s responsibility and organization skills.
-
Teaching methodologies
Teaching methodologies
Active learning methodologies based on the resolution of practical problems, on the exposition by the students of some concepts addressed in laboratory classes and the use of observations/results obtained in the laboratory as a starting point for the discussion of more complex concepts/topics.
-
References
References
Madigan, M.T. et al.. (2019) Brock Biology of Microorganisms, 15th Ed., Upper Saddle River, Prentice-Hall International Editions, 2014 David M. Knipe, Peter M. Howley (2023), Fields Virology, 7th Ed., Lippincott Williams & Wilkins. Acheson, N H, (2011) Fundamentals of Molecular Virology, 2nd Ed, John Wiley & Sons, Inc Artigos científicos fornecidos pelo docente.
-
Assessment
Assessment
Descrição
Data limite
Ponderação
2 Testes escritos
70%
Desempenho nas aulas práticas
15%
Apresentação de trabalho 15%
Aprovação na UC requer uma classificação mínima de 9,5 valores.
A) Regime de avaliação contínua – nota final resulta da média ponderada dos seguintes componentes:
- Dois testes escritos abrangendo toda a matéria leccionada nas aulas teóricas e laboratoriais (componentes T1 e T2) – 35% x2 - um mínimo de 9 valores de nota média destes dois componentes é requerida para aprovação à UC
- Desempenho nas aulas laboratoriais – 15% (A)
- Apresentação (+ discussão) de trabalho – 15%(B)
Nota Final = T1(35%) + T2(35%) + A(15%) + B(15%)
B) Regime de exame e exame de melhoria
- Prova escrita englobando a totalidade dos conteúdos programáticos, leccionados.
- O exame de melhoria de nota decorre em prova oral em época de recurso, englobando a totalidade dos conteúdos programáticos.
Evaluation: a minimum of 9.5 values is required for approval to the CU.
A) Continuous evaluation – including the following components:
- Two written tests – 35% x2 (T1 e T2) – a minimum average of 9 values is required for approval to the CU
- Practical classes performance – 15% (A)
- Essay presentation and discussion – 15% (B)
Final grade = T1(35%) + T2(35%) + A(15%) + B(15%)
B) Exam and grade improvement exam
- Final written exam covering all the topics lectured on both lectures and practical classes.
- Improvement exam: oral exam covering all the topics lectured on both lectures and practical classes.
-
Mobility
Mobility
No
