Class Disease Mechanisms

Knowledge about disease mechanisms are crucial for training in human health, essential for structuring deductive thinking related to the analysis of the mechanisms of alteration of the normal physiological functions within  the individual as a whole. This mechanistic view stems from the identification of the signs and symptoms that characterize the different periods of the disease's evolution, using the differential means of diagnosis (laboratorial, functional, imagiological) available. This presupposes an in-depth knowledge of the integrated physiology on which this practice is developed. 

Not applicable

Disease as a maladaptive response; genetics and the environment: susceptibility and multifactorial diseases. Neoplasia and genetic mutations; oncogenes and suppressor genes; Primary and secondary immunodeficiencies.  inflammation, regeneration, repair and healing. Hematological disease: coagulation factors, figured elements of the blood;  Endocrine disorders and current morbility expression - e.g. diabetes  Heart failure, ischemic heart disease, high blood pressure and shock Restrictive / obstructive pulmonary disease - COPD, emphysema, pneumoconiosis and asthma  Glomerulonephritis, renal tubular diseases and kidney failure; acid-base disorders. Renal disfunction and metabolic impact ;  Disease of the gastrointestinal tract to inflammatory bowel disease. Liver and bile duct disease.  Metabolic disease - inate and acquired (importance of obesity)  Neurodegenerative diseases and aging. Psiquiatric and behavioral diseases. Dermatological diseases

This curricular unit (CU) uses various active learning strategies such as the virtual human body from Anatomage, among others, to stimulate logical deductive reasoning; this CU also includes "field work" by study visits and/or seminars with external lecturers, inserted in the Lusofona Week of Contact with Pharmaceutical Professions 

Pathophysiology of Disease ¿ An Introduction to Clinical Medicine¿, Stephen J. McPhee e William F. Ganong (Eds), Lange Medical Books/McGraw-Hill. 2018  Kumar & Clark¿s Clinical Medicine¿, Parveen Kumar and Michael Clark (Eds), Saunders/Elsevier, 2018  Fisiopatologia - Fundamentos e Aplicações (2ª Edição)¿, Anabela Mota Pinto (Ed), Lidel. 2016