Class Clinical Biochemistry

Clinical Biochemistry will focus on the relationship between biochemical processes at the cellular level and the physiological processes that occur in mammals (more specifically in the human body), focusing on examples of altered biochemical processes in human diseases. In this sense, the student will have an integrated view of the various metabolic pathways and their regulation, with a greater emphasis on clinical correlations, which describe aberrant biochemical states in disease states (with biochemical and genetic detail), learning that biochemical parameters should be analyzed and monitored. This unit will have an important practical component where the student will use methodologies and analyze parameters used in a clinical laboratory, in order to develop the critical spirit, and the coherent form of presentation of results, which is fundamental in any professional area.

•  Introduction to Clinical Biochemistry

       Physiological factors affecting the composition of physiological fluids; Methods; Reference values

•  Protein functions. Correlation with diseases.

      Diagnostic application of some proteinase; Protein study methods

•  Genetic transmission. Genetic diseases

         Hereditary defects in different classes of proteins; Congenital Errors of Metabolism

•  Review of metabolic pathways and their control.

      Metabolism of Glycosides, Lipids; and Proteins.

•  Metabolic correlations .; Diabetes; Deslipidémias; Hormones

Biochemistry of Diabetes; Diabetes melittus type I and type II; Gestational and secondary diabetes mellitus. Functional tests; Glycated proteins; Pathogenesis of late complications

Lipid-lowering Lipoproteins; Determination of lipids and lipoproteins; Pathologies

Hormones - Mechanism and general characteristics; - Steroids

• Biochemistry of hepatic and renal function

 Metabolic function of the liver; Changes. Functions and tests renal function

Problem solving in laboratory context.

Introduce films and demonstrations in the Program Integration of syllabus to other diagnostic situations

Devlin, Thomas. Textbook of Chemistry with Clinical Correlations. 7th Ed., Wiley 2010. ISBN-13: 978-0470281734 

Allan Gaw, Michael J. Murphy, Robert A. Cowan, Denis St. J. O'Reilly, Michael J. Stewart, James Shepherd. Manital- Clinical Biochemistry: An Illustrated Colour Text. 4th Ed.Churchill Livingstone Elsevier, 2008. ISBN 13: 978-0443069321

Chawla, Ranjna . Practical Clinical Biochemistry - Methods and Interpretations. 4th Ed., Jaypee Brothers Medical Publishers. 2014 ISBN-13: 978-9350909423

Shivananda, Nswami . Manipal Manual Of  Clinical Biochemistry. 4th Ed., Jaypee Brothers Medical 2013 ISBN 9789350906675