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Presentation
Presentation
The Genetics and Genotoxicity course aims to provide students with fundamental knowledge about the genetic mechanisms that regulate heredity, gene expression and the integrity of genetic material, as well as the effects of genotoxic agents on DNA.
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Bachelor | Semestral | 5
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Year | Nature | Language
Year | Nature | Language
3 | Optional | Português
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Code
Code
ULHT1706-26804
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
1. Human Genetics Understanding Heredity Chromosome Structure and Karyotype DNA Repair Systems and Maintenance of Genomic Integrity 2. Molecular Genetics Genomics and Proteomics: Fundamentals and Applications The Role of RNA in Gene Expression Site-Directed Mutagenesis: Methods of Mutation Induction and Control Cell Transfection and Gene Expression in Biomedical Research 3. Recombinant DNA Technologies Fundamental Concepts and Applications of Recombinant DNA Technologies Understand the Process of Constructing Recombinant Molecules Recognize the Importance of Recombinant DNA Technologies for Biomedical Research 4. Genetic Toxicology Genotoxic Effects and Toxicity in the Human Genome DNA Damage Mechanisms and Cellular Repair Systems Mutagens, Carcinogens, and Genetic Susceptibility Laboratory Practice Component: Molecular Genetic Techniques; Genotoxicity Tests
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Objectives
Objectives
This course aims to provide students with a solid understanding of the fundamental concepts of human genetics and genotoxicity, and how these concepts are applied in biomedical and public health contexts. Students will: Acquire skills in human genetics, with a focus on scientific developments in areas such as genomics and proteomics, understanding fundamental concepts and procedures; Understand the dynamics and significance of damage to the human genome caused by chemical and physical agents, differentiating between carcinogenic and non-carcinogenic genotoxic agents; Assess risk as a function of dose and understand effective measures to minimize or eliminate exposure to these agents, as well as biomonitoring techniques for exposed populations; Develop practical skills in analyzing genetic and genotoxicity data, such as human genome data, mutation analysis, and predicting their effects on proteins and the genotoxicity of various agents.
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Teaching methodologies and assessment
Teaching methodologies and assessment
The course is assessed on a continuous basis, with two components: theoretical (TC) and laboratory (LC). The CT assessment comprises two examinations (75%) and a written group assignment on specific topics related to genetics and genotoxicity (25%). The CL assessment comprises two elements: the submission of reports (50 %) and a test (40 %). Should a student fail to attain a minimum grade of 9.5, they will be afforded the opportunity to take a practical examination. Furthermore, a continuous assessment component related to participation and performance in practical classes (10 %) will be taken into consideration. The final grade is the result of a weighted average, with 50 % attributed to the CT and 50 % to the CL. Students may opt for the non-continuous assessment, which consists of a final examination requiring a minimum of 9.5 values for approval.
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References
References
1. Lodish, H., Berk, A., Kaiser, C. A., Krieger, M., Scott, M. P., Bretscher, A., & Ploegh, H. (2021). Molecular Cell Biology (9th ed.). W. H. Freeman and Company. 2. Turnpenny, P. D., & Ellard, S. (2017). Emery's Elements of Medical Genetics (15th ed.). Elsevier 3. Vogel, F., & Motulsky, A. G. (2010). Human Genetics: Problems and Approaches (4th ed.). Springer. 4. Ellinger-Ziegelbauer, H., Aubrecht, J., Kleinjans, J. C., & Ahr, H. J. (2009). Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity. Toxicology letters, 186(1), 36–44. https://doi.org/10.1016/j.toxlet.2008.08.017.
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Office Hours
Office Hours
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Mobility
Mobility
No
