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Presentation
Presentation
The curricular unit (CU) of Applied Toxicology aims to provide students with the basic knowledge of Toxicology, associated with the most relevant topics of toxicology in the context of non-drug products (NDPs). This course will thus provide students with the expertise in toxicology that is needed for the understanding and subsequent employment in the safety assessment of NDPs.
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Master Degree | Semestral | 6
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Year | Nature | Language
Year | Nature | Language
1 | Mandatory | Português
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Code
Code
ULHT2629-17177
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
Unit 1. Principles of Toxicology
1.1.History and basic concepts
1.2.Toxicity tests
1.3.Dose / Response relationships
1.4.Exposure routes and toxicokinetics
1.5.Mechanisms of toxicity
1.6.Risk assessment
1.7.Biomarkers
Unit 2. Types of toxic effects
2.1. Non-Organ-Directed Toxicity: mutagenesis, carcinogenesis
2.2. Development and Reproductive Toxicology. Endocrine disruptors.
2.3. Organ-Directed Toxicity: liver, gastro-intestinal, cardiovascular, respiratory, dermal, neurological and renal
Unit 3. Toxicology applied to non-drug products
3.1.Methods for the toxicological evaluation: cytotoxicity, genotoxicity, dermatotoxicology assays
3.2.Relevant types of toxicants: metals, toxins from plants, animals and fungi, pesticides residues, industrial toxicants, toxic products from packaging materials
3.3.Toxicogenomics
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Objectives
Objectives
It is intended that students:
- Know the basic concepts of toxicology
- Understand the occurrence of the main types of toxic effects
- Be able to describe the most important toxic agents in the context of NDPs, regarding the exposure, mechanisms of toxicity, and effects on human health
- Comprehend the process of risk assessment and the most relevant methodologies for the safety evaluation of NDPs
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Teaching methodologies and assessment
Teaching methodologies and assessment
Active learning methodologies based on Case Based Learning and gamification.
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References
References
- Oliveira RD, Carvalho FD, Bastos ML. (2018) Toxicologia Fundamental. Lidel.
- Lee, B-M., Kacew, S.,, Kim, H.S. (2017). Lu's Basic Toxicology (7th edition), CRC Press.
- Klaassen, C.D. & Watkins, J.B. (2021) Casarett & Doull's: Essentials of Toxicology (4th edition). McGraw-Hill Education
- Shibamoto, T., Bjeldanes, L. F. (2009) Introduction to Food Toxicology (2ndedition), Elsevier.
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Office Hours
Office Hours
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Mobility
Mobility
No