Class Applied Toxicology

The curricular unit (CU) of Applied Toxicology aims to provide students with the basic knowledge of Toxicology, associated with the most relevant topics of toxicology in the context of non-drug products (NDPs). This course will thus provide students with the expertise in toxicology that is needed for the understanding and subsequent employment in the safety assessment of NDPs.

Unit 1. Principles of Toxicology

1.1.History and basic concepts

1.2.Toxicity tests

1.3.Dose / Response relationships

1.4.Exposure routes and toxicokinetics

1.5.Mechanisms of toxicity

1.6.Risk assessment

1.7.Biomarkers

Unit 2. Types of toxic effects

2.1. Non-Organ-Directed Toxicity: mutagenesis, carcinogenesis

2.2. Development and Reproductive Toxicology. Endocrine disruptors.

2.3. Organ-Directed Toxicity: liver, gastro-intestinal, cardiovascular, respiratory, dermal, neurological and renal

Unit 3. Toxicology applied to non-drug products

3.1.Methods for the toxicological evaluation: cytotoxicity, genotoxicity, dermatotoxicology assays

3.2.Relevant types of toxicants: metals, toxins from plants, animals and fungi, pesticides residues, industrial toxicants, toxic products from packaging materials

3.3.Toxicogenomics

Active learning methodologies based on Case Based Learning and gamification.

• Oliveira RD, Carvalho FD, Bastos ML. (2018) Toxicologia Fundamental. Lidel. 
• Lee, B-M., Kacew, S.,, Kim, H.S. (2017). Lu's Basic Toxicology (7th edition), CRC Press.
• Klaassen, C.D. & Watkins, J.B. (2021) Casarett & Doull's: Essentials of Toxicology (4th edition). McGraw-Hill Education
• Shibamoto, T., Bjeldanes, L. F. (2009) Introduction to Food Toxicology (2^ndedition), Elsevier.