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Presentation
Presentation
Organic Chemistry focuses on the study of the structure, reactivity, and synthesis of the main classes of organic compounds. Building upon the knowledge acquired in Structural Analysis, this course emphasizes reaction mechanisms, structure-reactivity relationships, and synthetic strategies employed in modern organic chemistry. The curricular unit is particularly relevant for medicinal chemistry, drug discovery, natural products chemistry, biotechnology, and pharmaceutical sciences. By integrating mechanistic concepts with structural characterization techniques, students develop a comprehensive understanding of molecular transformations and their analytical characterization.
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Master Degree | Semestral | 6
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Year | Nature | Language
Year | Nature | Language
1 | Mandatory | Português
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Code
Code
ULHT6812-26
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
Description of the Contents Major organic functional groups and nomenclature Reactivity of organic compounds Alkanes Alkyl halides (SN1 and SN2 substitution reactions; E1 and E2 elimination reactions) Alcohols, phenols, ethers, and epoxides Carbonyl compounds: aldehydes, ketones, carboxylic acids, and their derivatives Amines Stereochemistry: isomerism, chirality, optical rotation, and circular dichroism Spectroscopic characterization of organic compounds One-dimensional and two-dimensional Nuclear Magnetic Resonance (NMR) spectroscopy (COSY, HSQC, HMBC, andNOESY) Mass spectrometry Hyphenated techniques: GC-MS and LC-MS Applications to natural products and pharmaceuticals
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Objectives
Objectives
Upon successful completion of this course, students should be able to: Understand the fundamental principles governing organic reactivity. Explain nucleophilic substitution and elimination mechanisms. Describe the reactivity of the main organic functional groups. Interpret characteristic fragmentation patterns in mass spectrometry. Apply advanced spectroscopic techniques to the characterization of organic compounds. Integrate reactivity and structural analysis knowledge in organic compound identification.
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Teaching methodologies
Teaching methodologies
The teaching includes several tools, based on presential teaching, (theoretical, theoretical-practical and laboratorial classes) and other non-presential tools (e.g. moodle). In the tutorial component, fundamental concepts of the program are detailed studied by performing representative reactions, learning experimental techniques used in Organic Chemistry, and solving pre-announced problems. Throughout the teaching of the UC, practical and demonstrative examples of the matter are used.
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References
References
David R. Klein, (2017) Organic Chemistry (3rd edition) Wiley Vollhardt, K. P. C., Schore, N. E., (2014) Organic Chemistry: structure and function, (6th edition), W. H. Freeman. Solomons, T. W. G., Fryhle C. B., Snyder, S.A. (2013) Organic chemistry, (11th ed.), Wiley.
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Assessment
Assessment
A avaliação é efetuada por avaliação contínua, que engloba: (A) apresentação e discussão de um trabalho escrito (30%); (B) Teste (40%); (C) Preparação e discussão de caderno de laboratório (20%); (D) Desempenho nas aulas (10%).
Nota Final = A (30%) + B (40%) + C (20%) + D (10%).
O aluno trabalhador-estudante que opte pela avaliação contínua deve cumprir os requisitos acima definidos. A melhoria de nota realiza-se na forma de exame oral, reunindo todos os conteúdos programáticos.
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Mobility
Mobility
No
